Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.40 |
| ▸ | ABL1 | P00519 | 9/20 | 0.40 |
| ▸ | EGFR | P00533 | 9/20 | 0.40 |
| ▸ | HCK | P08631 | 9/20 | 0.40 |
| ▸ | SRC | P12931 | 9/20 | 0.40 |
| ▸ | KDR | P35968 | 9/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.40 |
| ▸ | MTOR | P42345 | 9/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 9/20 | 0.40 |
| ▸ | PRKDC | P78527 | 9/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1407383 | 0.86 | ESR1 (0.64) | ESR1PIK3CDABL1EGFRHCK | |
| SCHEMBL4031733 | 0.81 | ESR1 (0.51) | ESR1PIK3CDABL1EGFRHCK | |
| SCHEMBL1407427 | 0.78 | ESR1 (0.46) | ESR1ADRA1AKCNH2HRH3KDM4E | |
| SCHEMBL4025587 | 0.71 | ESR1 (0.64) | ESR1PIK3CDABL1EGFRHCK | |
| SCHEMBL4028322 | 0.70 | ESR1 (0.71) | ESR1PIK3CDABL1EGFRHCK | |
| SCHEMBL4030618 | 0.69 | CYP1A1 (0.42) | ESR1KDM4E | |
| SCHEMBL4030702 | 0.68 | ESR1 (0.66) | ESR1PIK3CDABL1EGFRHCK | |
| SCHEMBL4027904 | 0.68 | ESR1 (1.00) | ESR1PIK3CDABL1EGFRHCK | |
| SCHEMBL4029431 | 0.68 | ESR1 (0.71) | ESR1PIK3CDABL1EGFRHCK | |
| SCHEMBL4025780 | 0.67 | ESR1 (0.97) | ESR1PIK3CDABL1EGFRHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040167127-A1 | Substituted 4-(indazol-3-yl)phenols | WYETH (US) | 2004-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167127-A1 | Substituted 4-(indazol-3-yl)phenols | INSR, MSR1, TNNI3 | ESR1 2487/4885PIK3CD 2207/4885ABL1 1747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.