SCHEMBL6704495

SCHEMBL6704495

CC(=O)OCC(=O)N1CCN(c2c(F)cc(N3C[C@H](CNC(=S)C(F)F)OC3=O)cc2F)CC1

nearest known ligand 0.45

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
F10 P00742 3/20 0.45
MAOA P21397 7/20 0.44
MAOB P27338 6/20 0.44
LMNA P02545 1/20 0.44
PTGS1 P23219 1/20 0.44
CALML3 P27482 1/20 0.44
SDHA P31040 1/20 0.44
TOP2B Q02880 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6704498 1.00 F10 (0.45) F10MAOAMAOBLMNAPTGS1
SCHEMBL7710023 0.93 F10 (0.45) F10MAOAMAOBLMNAPTGS1
SCHEMBL7710018 0.93 F10 (0.45) F10MAOAMAOBLMNAPTGS1
SCHEMBL7704370 0.92 F10 (0.49) F10MAOAMAOBLMNAPTGS1
SCHEMBL7704368 0.92 F10 (0.49) F10MAOAMAOBLMNAPTGS1
SCHEMBL7710459 0.90 F10 (0.48) F10MAOAMAOBLMNAPTGS1
SCHEMBL7710463 0.90 F10 (0.48) F10MAOAMAOBLMNAPTGS1
SCHEMBL6701819 0.90 F10 (0.54) F10MAOAMAOBLMNAPTGS1
SCHEMBL7704253 0.89 F10 (0.47) F10MAOAMAOBLMNAPTGS1
SCHEMBL7704256 0.89 F10 (0.47) F10MAOAMAOBLMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040072842-A1 Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent PHARMACIA & UPJOHN COMPANY 2004-04-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040072842-A1 Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent GMDS, PGLS, DDOST F10 4107/4885MAOA 3409/4885MAOB 3566/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.