Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.72 |
| ▸ | EGFR | P00533 | 16/20 | 0.45 |
| ▸ | CSF1R | P07333 | 11/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
| ▸ | NEK3 | P51956 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14123465 | 0.74 | EGFR (0.79) | KDREGFRCSF1RPRMT5ERBB2 | |
| SCHEMBL13604162 | 0.72 | CSF1R (0.57) | EGFRCSF1R | |
| SCHEMBL3845085 | 0.72 | EGFR (0.80) | KDREGFRCSF1RSTK10MAP4K4 | |
| SCHEMBL28750275 | 0.72 | EGFR (0.80) | KDREGFRCSF1RSTK10MAP4K4 | |
| SCHEMBL20305681 | 0.68 | EGFR (0.60) | KDREGFRCSF1RERBB2 | |
| SCHEMBL4808315 | 0.68 | PRMT5 (0.53) | KDREGFRCSF1RPRMT5 | |
| SCHEMBL4763947 | 0.68 | PRMT5 (0.64) | EGFRPRMT5ERBB2ERBB4 | |
| SCHEMBL17289601 | 0.66 | TBK1 (0.46) | KDREGFRCSF1R | |
| SCHEMBL4764399 | 0.66 | EGFR (0.63) | KDREGFRCSF1RABL1ERBB2 | |
| SCHEMBL1899495 | 0.65 | EGFR (0.55) | EGFRCSF1RPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040242600-A1 | 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242600-A1 | 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives | DPYD, TYMP, TYMS | KDR 2234/4885EGFR 2694/4885CSF1R 3516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.