Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.76 |
| ▸ | PDGFRB | P09619 | 11/20 | 0.60 |
| ▸ | KIT | P10721 | 3/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.60 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2914101 | 0.86 | ENPP1 (0.60) | KDM1APDGFRBENPP1ACHEBACE1 | |
| SCHEMBL2389420 | 0.85 | ACHE (0.72) | ENPP1ACHEBACE1PDE10AUSP2 | |
| SCHEMBL3366836 | 0.83 | PDGFRB (0.58) | KDM1APDGFRBKITPDGFRAENPP1 | |
| SCHEMBL3368100 | 0.83 | CYP1A2 (0.59) | KDM1APDGFRBUSP2ALDH1A1CYP1A2 | |
| SCHEMBL1132488 | 0.82 | KIT (0.65) | PDGFRBKITENPP1 | |
| SCHEMBL22946682 | 0.82 | KDM1A (1.00) | KDM1APDGFRBKITPDGFRAACHE | |
| SCHEMBL29478516 | 0.82 | KDM1A (1.00) | KDM1APDGFRBKITPDGFRAACHE | |
| SCHEMBL15667852 | 0.81 | TLR9 (0.71) | PDGFRBKITPDGFRAENPP1CLK4 | |
| SCHEMBL30080059 | 0.81 | ENPP1 (0.77) | ENPP1ACHEBACE1PDE10AUSP2 | |
| SCHEMBL2921150 | 0.81 | ENPP1 (0.77) | ENPP1ACHEBACE1PDE10AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040259881-A1 | Nitrogenous heterocyclic compounds | KYOWA HAKKO KOGYO CO, LTD. (JP) | 2004-12-23 | — | — | US | disclosed |
| EP-1309567-A2 | NITROGENOUS HETEROCYCLIC COMPOUNDS | Millennium Pharmaceuticals, Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002016360-A2 | NITROGENOUS HETEROCYCLIC COMPOUNDS | COR THERAPEUTICS, INC. (US) | 2002-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259881-A1 | Nitrogenous heterocyclic compounds | WNK2, CDK5, PDGFRA | KDM1A 4148/4885PDGFRB 5/4885KIT 657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.