Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6706744 | 0.91 | MCHR1 (0.81) | MCHR1CYP2D6SMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL6704627 | 0.81 | MCHR1 (0.67) | MCHR1CYP2D6SMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL3867760 | 0.80 | MCHR1 (0.62) | MCHR1CYP2D6SMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL11486928 | 0.80 | NPC1 (0.73) | MCHR1CYP2D6SMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL7702871 | 0.79 | ESRRG (0.68) | MCHR1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL8163393 | 0.78 | MCHR1 (0.77) | MCHR1CYP2D6SMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL6223646 | 0.78 | MCHR1 (0.77) | MCHR1CYP2D6SMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL6705905 | 0.77 | MCHR1 (0.62) | MCHR1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL11707941 | 0.76 | CYP2D6 (0.91) | MCHR1CYP2D6SMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL3018104 | 0.76 | MCHR1 (0.77) | MCHR1CYP2D6SMN1; SMN2NPC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040242572-A1 | New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242572-A1 | New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture | MCHR2, MCHR1, NPY1R | MCHR1 2/4885CYP2D6 1590/4885SMN1; SMN2 3130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.