Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 8/20 | 0.65 |
| ▸ | NPC1 | O15118 | 7/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | MLYCD | O95822 | 1/20 | 0.57 |
| ▸ | ESRRB | O95718 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6706744 | 0.84 | MCHR1 (0.81) | ESRRGRAB9ANPC1HDAC8HDAC6 | |
| SCHEMBL13439903 | 0.84 | RAB9A (0.74) | ESRRGRAB9ANPC1HDAC8HDAC6 | |
| SCHEMBL6705905 | 0.82 | MCHR1 (0.62) | RAB9ANPC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL6705900 | 0.82 | HDAC8 (0.53) | ESRRGRAB9AHDAC8HDAC6MCHR1 | |
| SCHEMBL23257047 | 0.81 | ESRRG (0.61) | ESRRGRAB9ANPC1HDAC8HDAC6 | |
| SCHEMBL751214 | 0.80 | HDAC2 (0.80) | ESRRGRAB9ANPC1HDAC8HDAC6 | |
| SCHEMBL1927473 | 0.79 | RAB9A (0.67) | ESRRGRAB9ANPC1HDAC8HDAC6 | |
| SCHEMBL16900376 | 0.79 | RAB9A (1.00) | ESRRGRAB9ANPC1HDAC8HDAC6 | |
| SCHEMBL7282271 | 0.79 | HDAC2 (0.78) | RAB9ANPC1HDAC8HDAC6HDAC2 | |
| SCHEMBL6841899 | 0.79 | HDAC2 (0.78) | RAB9ANPC1HDAC8HDAC6HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |