Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 3/20 | 0.45 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.41 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6711979 | 0.96 | EHMT2 (0.46) | PDPK1RAF1EHMT2EHMT1RET | |
| SCHEMBL6708414 | 0.93 | EHMT2 (0.49) | PDPK1EHMT2EHMT1RETCHEK1 | |
| SCHEMBL6707527 | 0.92 | EHMT2 (0.48) | PDPK1EHMT2EHMT1CHEK1KDM4E | |
| SCHEMBL6706908 | 0.85 | KDM4E (0.47) | PDPK1EHMT2EHMT1RETKDM4E | |
| SCHEMBL6710222 | 0.83 | KDM4E (0.44) | EHMT2EHMT1KDM4EALDH1A1GLA | |
| SCHEMBL6707006 | 0.74 | KDM4E (0.57) | PDPK1KDM4EALDH1A1GLAGAA | |
| SCHEMBL6707513 | 0.72 | KDM4E (0.46) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL6708597 | 0.72 | KDM4E (0.57) | PDPK1KDM4EALDH1A1GLAGAA | |
| SCHEMBL6709162 | 0.72 | KDM4E (0.56) | PDPK1KDM4EALDH1A1GLAGAA | |
| SCHEMBL6712216 | 0.72 | KDM4E (0.56) | PDPK1RAF1EGFRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040248923-A1 | Novel 4-anilinoquinoline-3-carboxamides | ASTRAZENECA AB (SE) | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248923-A1 | Novel 4-anilinoquinoline-3-carboxamides | JAK3, JAK2, JAK1 | PDPK1 236/4885RAF1 345/4885EHMT2 3232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.