Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5026871 | 0.89 | NPC1 (0.52) | NCF1MAPK1LMNAUSP2TSHR | |
| SCHEMBL5028660 | 0.83 | NCF1 (0.51) | NCF1MAPK1LMNAUSP2TSHR | |
| SCHEMBL5024388 | 0.81 | CTNNB1 (0.49) | NCF1CTNNB1TCF7L2 | |
| SCHEMBL5022706 | 0.80 | NCF1 (0.51) | NCF1 | |
| SCHEMBL5024554 | 0.80 | NCF1 (0.51) | NCF1HTTSMN1; SMN2CTNNB1TCF7L2 | |
| SCHEMBL5026876 | 0.78 | NCF1 (0.46) | NCF1CTNNB1TCF7L2 | |
| SCHEMBL5022553 | 0.78 | NCF1 (0.51) | NCF1MAPK1HTTCTNNB1TCF7L2 | |
| SCHEMBL5025329 | 0.78 | NCF1 (0.53) | NCF1MAPK1 | |
| SCHEMBL5024412 | 0.78 | NCF1 (0.53) | NCF1MAPK1LMNAUSP2HTT | |
| SCHEMBL5026894 | 0.77 | NCF1 (0.48) | NCF1MAPK1LMNAUSP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474145-A1 | QUINOLINE DERIVATIVES AS NPY ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003066055-A1 | QUINOLINE DERIVATIVES AS NPY ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-14 | — | — | WO | disclosed |