Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 13/20 | 0.33 |
| ▸ | HTR3A | P46098 | 12/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | HRH2 | P25021 | 2/20 | 0.33 |
| ▸ | HTR1B | P28222 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | HTR5A | P47898 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4823304 | 0.78 | DRD4 (0.76) | DRD4HTR1AHTR2ADRD2 | |
| SCHEMBL5331948 | 0.74 | HTR1A (0.40) | DRD4HTR1AHTR3ACYP1A2CYP3A4 | |
| SCHEMBL14355725 | 0.74 | HTR1A (0.40) | DRD4HTR1AHTR3ACYP1A2CYP3A4 | |
| SCHEMBL14387771 | 0.69 | HTR1A (0.43) | DRD4HTR1AHTR3ACYP1A2CYP3A4 | |
| SCHEMBL5335072 | 0.69 | HTR1A (0.43) | DRD4HTR1AHTR3ACYP1A2CYP3A4 | |
| SCHEMBL5335772 | 0.69 | HTR1A (0.43) | DRD4HTR1AHTR3ACYP1A2CYP3A4 | |
| SCHEMBL4813879 | 0.64 | DRD4 (1.00) | DRD4HTR1AHTR2ADRD2 | |
| SCHEMBL336256 | 0.61 | HTR1A (0.66) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4819196 | 0.61 | DRD4 (0.76) | DRD4DRD2 | |
| SCHEMBL4824080 | 0.61 | DRD4 (0.74) | DRD4HTR1AHTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063713-A1 | Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction | ABBVIE INC. | 2004-04-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063713-A1 | Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction | CYP19A1, CYP17A1, HSD17B11 | DRD4 1401/4885HTR1A 293/4885HTR3A 483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.