Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13793993 | 0.83 | ALDH1A1 (0.41) | ALDH1A1ERN1TRIM24TYRTRIM33 | |
| SCHEMBL12090345 | 0.80 | ALDH1A1 (0.54) | ALDH1A1ERN1TRIM24TYRTRIM33 | |
| SCHEMBL14117773 | 0.78 | ALDH1A1 (0.49) | ALDH1A1ERN1TRIM24TYRTRIM33 | |
| SCHEMBL788386 | 0.78 | PDGFRA (0.48) | ALDH1A1ERN1ELANE | |
| SCHEMBL13794510 | 0.78 | ALDH1A1 (0.49) | ALDH1A1ERN1TRIM24TYRTRIM33 | |
| SCHEMBL10283795 | 0.76 | ALDH1A1 (0.47) | ALDH1A1ERN1TRIM24TYRTRIM33 | |
| SCHEMBL5331216 | 0.74 | ELANE (0.43) | KDM4CELANEKDM4EHSD17B10 | |
| SCHEMBL673690 | 0.74 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTDYRK1AMAPK1 | |
| SCHEMBL14963448 | 0.74 | ALDH1A1 (0.45) | ALDH1A1ERN1KDM4EMAPTPTGER4 | |
| SCHEMBL5951228 | 0.73 | MAP2K4 (0.39) | ALDH1A1ERN1ELANEKDM4EPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |