Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 15/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 14/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 14/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 14/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 14/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3137544 | 0.85 | CDK2 (0.53) | PDE4APDE4BPDE4CPDE4DCDK2 | |
| SCHEMBL3130740 | 0.83 | CDK2 (0.56) | PDE4APDE4BPDE4CPDE4DCDK2 | |
| SCHEMBL3133681 | 0.80 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL3136283 | 0.79 | CDK2 (0.46) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL3140675 | 0.76 | TLR7 (0.53) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL3142263 | 0.76 | CDK2 (0.43) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL3132183 | 0.76 | CDK2 (0.48) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL3131818 | 0.75 | YTHDC1 (0.56) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL3138215 | 0.75 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL3141362 | 0.74 | YTHDC1 (0.60) | PDE4APDE4BPDE4CPDE4DCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040242598-A1 | Phosphodiesterase 4 inhibitors | LIU RUIPING (US) | 2004-12-02 | — | — | US | claimed |
| US-20030045533-A1 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORP. | 2003-03-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045533-A1 | Phosphodiesterase 4 inhibitors | PDE4A, PDE3A, PDE3B | PDE4A 1/4885PDE4B 5/4885PDE4C 8/4885 |
| US-20040242598-A1 | Phosphodiesterase 4 inhibitors | PDE4A, PDE3A, PDE3B | PDE4A 1/4885PDE4B 5/4885PDE4C 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.