Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1627317 | 0.85 | — | — | |
| SCHEMBL14810515 | 0.85 | CYP2D6 (0.34) | TSHRCYP2D6USP2ALDH1A1HPGD | |
| SCHEMBL1629026 | 0.83 | CYP2D6 (0.39) | TSHRCYP2D6USP2ALDH1A1HPGD | |
| SCHEMBL623024 | 0.80 | — | — | |
| SCHEMBL18763507 | 0.80 | — | — | |
| SCHEMBL2639734 | 0.80 | — | — | |
| SCHEMBL314510 | 0.77 | TSHR (0.32) | TSHRCYP2D6USP2ALDH1A1HPGD | |
| SCHEMBL15556892 | 0.76 | — | — | |
| SCHEMBL112025 | 0.75 | — | — | |
| SCHEMBL149605 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11612606-B2 | 8-aminoisoquinoline compounds and uses thereof | GENENTECH, INC. (US) | 2023-03-28 | — | — | US | disclosed |
| EP-3860980-A1 | 8-AMINOISOQUINOLINE COMPOUNDS AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2021-08-11 | — | — | EP | disclosed |
| WO-2020138398-A1 | NOVEL COMPOUND INHIBITING LYSINE-SPECIFIC DEMETHYLATING ENZYME 1, METHOD FOR PRODUCING SAME, AND USE OF SAME | 国立研究開発法人理化学研究所 | 2020-07-02 | — | — | WO | disclosed |
| WO-2020072695-A1 | 8-AMINOISOQUINOLINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-04-09 | — | — | WO | disclosed |
| US-20200108075-A1 | 8-AMINOISOQUINOLINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-04-09 | — | — | US | disclosed |
| WO-2016190847-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2016-12-01 | — | — | WO | disclosed |
| EP-1683798-B1 | Fused polycyclic compounds having heterocycle and medicinal use thereof | AJINOMOTO KK (JP) | 2016-04-20 | — | — | EP | disclosed |
| EP-2605658-A1 | SPIROXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| US-20130041000-A1 | NOVEL AZOLE COMPOUND | AJINOMOTO CO., INC. (JP) | 2013-02-14 | — | — | US | disclosed |
| US-8299064-B2 | Fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2012-10-30 | — | — | US | disclosed |
| WO-2012024183-A1 | SPIROXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |
| US-20110160191-A1 | NEW FUSED POLYCYCLIC COMPOUNDS HAVING A HETEROCYCLIC RING(S) AND PHARMACEUTICAL USE THEREOF | AJINOMOTO CO., INC. (JP) | 2011-06-30 | — | — | US | disclosed |
| US-7928101-B2 | Fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2011-04-19 | — | — | US | disclosed |
| US-20090170911-A1 | NOVEL AZOLE COMPOUND | AJINOMOTO CO. INC (JP) | 2009-07-02 | — | — | US | disclosed |
| US-7517996-B2 | Azole compound | AJINOMOTO CO., INC. (JP) | 2009-04-14 | — | — | US | disclosed |
| US-20060194789-A1 | Fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2006-08-31 | — | — | US | disclosed |
| US-20060194850-A1 | Novel azole compound | AJINOMOTO CO. INC (JP) | 2006-08-31 | — | — | US | disclosed |
| EP-1683798-A1 | NOVEL FUSED POLYCYCLIC COMPOUND HAVING HETEROCYCLE AND MEDICINAL USE THEREOF | Ajinomoto Co., Inc. (JP) | 2006-07-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170911-A1 | NOVEL AZOLE COMPOUND | LPAR1, LPAR2, LPAR3 | TSHR 539/4885CYP2D6 2076/4885USP2 3686/4885 |
| US-20060194789-A1 | Fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof | SLC2A4, SLC2A3, SLC2A1 | TSHR 692/4885CYP2D6 280/4885USP2 4679/4885 |
| US-20110160191-A1 | NEW FUSED POLYCYCLIC COMPOUNDS HAVING A HETEROCYCLIC RING(S) AND PHARMACEUTICAL USE THEREOF | SLC2A4, SLC2A1, SLC2A3 | TSHR 785/4885CYP2D6 316/4885USP2 4649/4885 |
| US-20130041000-A1 | NOVEL AZOLE COMPOUND | LPAR1, LPAR2, LPAR3 | TSHR 539/4885CYP2D6 2076/4885USP2 3686/4885 |
| US-20200108075-A1 | 8-AMINOISOQUINOLINE COMPOUNDS AND USES THEREOF | PHKG1, MAP4K5, HIPK1 | TSHR 4838/4885CYP2D6 3682/4885USP2 1498/4885 |
| US-20060194850-A1 | Novel azole compound | LPAR1, LPAR2, LPAR3 | TSHR 539/4885CYP2D6 2076/4885USP2 3686/4885 |
| US-11612606-B2 | 8-aminoisoquinoline compounds and uses thereof | PHKG1, MAP4K5, HIPK1 | TSHR 4838/4885CYP2D6 3682/4885USP2 1498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.