Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.51 |
| ▸ | CTSE | P14091 | 1/20 | 0.51 |
| ▸ | PGC | P20142 | 1/20 | 0.51 |
| ▸ | REN | P00797 | 12/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6444542 | 1.00 | CTSD (0.51) | CTSDCTSEPGCRENKLK5 | |
| SCHEMBL6442709 | 1.00 | CTSD (0.51) | CTSDCTSEPGCRENKLK5 | |
| SCHEMBL6442715 | 1.00 | CTSD (0.51) | CTSDCTSEPGCRENKLK5 | |
| SCHEMBL7408240 | 0.90 | CTSD (0.61) | CTSDCTSEPGCRENKLK5 | |
| SCHEMBL6449190 | 0.90 | CTSD (0.61) | CTSDCTSEPGCRENKLK5 | |
| SCHEMBL6449191 | 0.90 | CTSD (0.61) | CTSDCTSEPGCRENKLK5 | |
| SCHEMBL6710768 | 0.85 | AKT1 (0.49) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6445090 | 0.85 | AKT1 (0.49) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6445086 | 0.85 | AKT1 (0.49) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6443872 | 0.84 | CTSD (0.57) | CTSDCTSEPGCRENKLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392315-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002100410-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-12-19 | — | — | WO | disclosed |