Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | STAT1 | P42224 | 1/20 | 0.52 |
| ▸ | CYCS | P99999 | 3/20 | 0.51 |
| ▸ | TERT | O14746 | 4/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15943807 | 0.98 | TOP1 (0.54) | TOP1STAT3STAT1CYCSTERT | |
| SCHEMBL5011842 | 0.98 | TOP1 (0.54) | TOP1STAT3STAT1CYCSTERT | |
| SCHEMBL31550997 | 0.97 | TOP1 (0.53) | TOP1STAT3STAT1CYCSTERT | |
| SCHEMBL31550985 | 0.97 | TOP1 (0.53) | TOP1STAT3STAT1CYCSTERT | |
| SCHEMBL5137028 | 0.97 | TOP1 (0.53) | TOP1STAT3STAT1CYCSTERT | |
| SCHEMBL31551010 | 0.97 | TOP1 (0.53) | TOP1STAT3STAT1CYCSTERT | |
| SCHEMBL31550989 | 0.97 | TOP1 (0.53) | TOP1STAT3STAT1CYCSTERT | |
| SCHEMBL31550978 | 0.97 | TOP1 (0.53) | TOP1STAT3STAT1CYCSTERT | |
| SCHEMBL31550990 | 0.97 | TOP1 (0.53) | TOP1STAT3STAT1CYCSTERT | |
| SCHEMBL30136 | 0.88 | TOP1 (0.64) | TOP1STAT3STAT1CYCSTERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040067198-A1 | Emissive multichromophoric systems | THERIEN MICHAEL J (US) | 2004-04-08 | — | — | US | disclosed |
| EP-0656037-B1 | METAL-MEDIATED CROSS-COUPLING WITH RING-METALATED PORPHYRINS | UNIV PENNSYLVANIA (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-1308481-A2 | Metal-mediated cross-coupling with ring-metalated porphyrins | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2003-05-07 | — | — | EP | disclosed |
| US-5986090-A | Metal-mediated cross-coupling with ring-metalated porphyrins | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1999-11-16 | — | — | US | disclosed |
| US-5756723-A | Metal-mediated cross-coupling with ring-metalated porphyrins | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0656037-A4 | METAL-MEDIATED CROSS-COUPLING WITH RING-METALATED PORPHYRINS. | UNIV PENNSYLVANIA (US) | 1997-07-30 | — | — | EP | disclosed |
| US-5493017-A | Ring-metalated porphyrins | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1996-02-20 | — | — | US | disclosed |
| EP-0656037-A1 | METAL-MEDIATED CROSS-COUPLING WITH RING-METALATED PORPHYRINS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004614-A1 | METAL-MEDIATED CROSS-COUPLING WITH RING-METALATED PORPHYRINS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1994-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067198-A1 | Emissive multichromophoric systems | MC3R, EML4, TYR | TOP1 2833/4885STAT3 2744/4885STAT1 4583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.