Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.85 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.85 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.85 |
| ▸ | PDE1A | P54750 | 2/20 | 0.71 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.71 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.71 |
| ▸ | PDE2A | O00408 | 1/20 | 0.71 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.71 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.71 |
| ▸ | PDE6D | O43924 | 1/20 | 0.71 |
| ▸ | PDE8A | O60658 | 1/20 | 0.71 |
| ▸ | PDE9A | O76083 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | HTR1A | P08908 | 1/20 | 0.71 |
| ▸ | PDE6A | P16499 | 1/20 | 0.71 |
| ▸ | PDE6G | P18545 | 1/20 | 0.71 |
| ▸ | PDE4A | P27815 | 1/20 | 0.71 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.71 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6716971 | 0.95 | PDE5A (0.76) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6717005 | 0.94 | PDE5A (0.75) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6715673 | 0.93 | PDE5A (0.74) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6719179 | 0.93 | PDE5A (0.84) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6716708 | 0.93 | PDE5A (0.73) | PDE5APDE3BPDE3APDE1APDE1B | |
| Lodenafil SCHEMBL31202790 | 0.92 | PDE5A (1.00) | PDE5APDE3BPDE3APDE1APDE1B | |
| Lodenafil SCHEMBL1058 | 0.92 | PDE5A (1.00) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6716511 | 0.92 | PDE5A (0.84) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6722978 | 0.92 | PDE5A (0.72) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL28414649 | 0.90 | PDE5A (0.70) | PDE5APDE3BPDE3APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111732593-A | Piperazine oxide derivative and composition, preparation method and application thereof | 黄泳华 | 2020-10-02 | — | — | CN | claimed |
| EP-1395593-A4 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INST SCI & TECH (KR) | 2004-11-10 | — | — | EP | claimed |
| EP-1395593-A1 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-03-10 | — | — | EP | claimed |
| WO-2002102802-A1 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2002-12-27 | — | — | WO | claimed |
| US-20230041334-A1 | METHODS AND COMPOSITIONS FOR SMOKING CESSATION | BEHAVIORAL DIAGNOSTICS, LLC (US) | 2023-02-09 | — | — | US | disclosed |
| CN-111732593-A | Piperazine oxide derivative and composition, preparation method and application thereof | 黄泳华 | 2020-10-02 | — | — | CN | disclosed |
| EP-1395593-A4 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INST SCI & TECH (KR) | 2004-11-10 | — | — | EP | disclosed |
| US-20040176371-A1 | Novel pyrazolopyrimidinethione derivatives, preparation methods thereof and their use as therapeutics for erectile dysfunction | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-09-09 | — | — | US | disclosed |
| EP-1395593-A1 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002102802-A1 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2002-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176371-A1 | Novel pyrazolopyrimidinethione derivatives, preparation methods thereof and their use as therapeutics for erectile dysfunction | PDE3B, PDE3A, PDE5A | PDE5A 3/4885PDE3B 1/4885PDE3A 2/4885 |
| US-20230041334-A1 | METHODS AND COMPOSITIONS FOR SMOKING CESSATION | PDE5A, PDE3A, PDE2A | PDE5A 1/4885PDE3B 4/4885PDE3A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.