Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.55 |
| ▸ | KRAS | P01116 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.55 |
| ▸ | TUBB | P07437 | 1/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.55 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27860092 | 1.00 | TNFRSF1A (0.59) | TNFRSF1ANPC1MAPTRAB9ALMNA | |
| SCHEMBL7187236 | 0.89 | TNFRSF1A (0.62) | TNFRSF1ANPC1MAPTRAB9ALMNA | |
| SCHEMBL7187233 | 0.89 | TNFRSF1A (0.62) | TNFRSF1ANPC1MAPTRAB9ALMNA | |
| SCHEMBL27816898 | 0.88 | KRAS (0.67) | TNFRSF1AMAPTLMNAABCG2KRAS | |
| SCHEMBL8066940 | 0.87 | PTPN1 (0.55) | NPC1MAPTRAB9ALMNAABCG2 | |
| SCHEMBL7194858 | 0.84 | TNFRSF1A (0.59) | TNFRSF1ANPC1MAPTRAB9ALMNA | |
| SCHEMBL7193630 | 0.84 | TNFRSF1A (0.59) | TNFRSF1ANPC1MAPTRAB9ALMNA | |
| SCHEMBL27574595 | 0.84 | CYP3A4 (0.49) | TNFRSF1ANPC1MAPTRAB9ALMNA | |
| SCHEMBL7190221 | 0.84 | CYP3A4 (0.49) | TNFRSF1ANPC1MAPTRAB9ALMNA | |
| SCHEMBL31402521 | 0.83 | KDM4E (0.61) | ABCG2CYP2C9TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102267888-A | Chalcone derivative as well as preparation method and application thereof used as inducer in inducing apoptosis of tumor cells | — | 2011-12-07 | — | — | CN | claimed |
| CN-112047916-A | Method for synthesizing isolicoflavonol | 苏州昊帆生物股份有限公司 | 2020-12-08 | — | — | CN | disclosed |
| CN-102267888-A | Chalcone derivative as well as preparation method and application thereof used as inducer in inducing apoptosis of tumor cells | — | 2011-12-07 | — | — | CN | disclosed |
| CN-102267888-A | Chalcone derivative as well as preparation method and application thereof used as inducer in inducing apoptosis of tumor cells | — | 2011-12-07 | — | — | CN | disclosed |
| US-20040242907-A1 | Methods of synthesizing flavonoids and chalcones | UNITECH PHARMACEUTICALS, INC. | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242907-A1 | Methods of synthesizing flavonoids and chalcones | CYP46A1, CYP7B1, CYP2F1 | TNFRSF1A 2847/4885NPC1 1095/4885MAPT 3328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.