Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11639387 | 0.91 | MEN1 (0.60) | SLC6A4HRH3HTR2CMEN1CYP3A4 | |
| SCHEMBL29356733 | 0.91 | MEN1 (0.60) | SLC6A4HRH3HTR2CMEN1CYP3A4 | |
| Hydrochloric Acid SCHEMBL11798762 | 0.90 | SLC6A4 (0.53) | SLC6A4HRH3HTR2CMEN1CYP3A4 | |
| SCHEMBL8905123 | 0.88 | CA12 (0.44) | SLC6A4HRH3HTR2CSLC6A2SLC6A3 | |
| SCHEMBL747837 | 0.86 | SLC6A2 (0.61) | SLC6A4SLC6A2SLC6A3 | |
| Bromide SCHEMBL8904521 | 0.85 | PARP1 (0.54) | SLC6A4HRH3HTR2CCYP3A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL11804968 | 0.85 | SLC6A2 (0.60) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL1037048 | 0.85 | SLC6A4 (0.54) | SLC6A4HRH3 | |
| Hydrochloric Acid SCHEMBL11800570 | 0.85 | CA1 (0.50) | SLC6A4HRH3HTR2CMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11794816 | 0.83 | DRD2 (0.44) | SLC6A4HRH3HTR2CMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040192685-A1 | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists | CAMERON KIMBERLY O (US) | 2004-09-30 | — | — | US | disclosed |
| US-20030220494-A1 | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists | CAMERON KIMBERLY O (US) | 2003-11-27 | — | — | US | disclosed |
| US-6608203-B2 | Devoid of unwanted side effects | PFIZER INC. | 2003-08-19 | — | — | US | disclosed |
| US-20010039285-A1 | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists | CAMERON KIMBERLY O (US) | 2001-11-08 | — | — | US | disclosed |
| EP-1113007-A1 | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists | PFIZER INC. (US) | 2001-07-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010039285-A1 | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists | GPER1, ESR1, ESR2 | SLC6A4 3240/4885HRH3 528/4885HTR2C 168/4885 |
| US-20030220494-A1 | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists | GPER1, ESR1, ESR2 | SLC6A4 3240/4885HRH3 528/4885HTR2C 168/4885 |
| US-20040192685-A1 | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists | GPER1, ESR1, ESR2 | SLC6A4 3240/4885HRH3 528/4885HTR2C 168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.