SCHEMBL671549

SCHEMBL671549

NS(=O)(=O)c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CA2 P00918 14/20 1.00
CA12 O43570 13/20 1.00
CA1 P00915 13/20 1.00
CA9 Q16790 13/20 1.00
KMT2A Q03164 3/20 1.00
MEN1 O00255 2/20 1.00
L3MBTL1 Q9Y468 2/20 0.72
MAPT P10636 1/20 0.72
CA4 P22748 1/20 0.70
CA7 P43166 1/20 0.70
PTPN7 P35236 1/20 0.70
KDM4E B2RXH2 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28499329 0.91 KMT2A (1.00) CA2CA12CA1CA9KMT2A
SCHEMBL674020 0.85 CA2 (1.00) CA2CA12CA1CA9KMT2A
SCHEMBL673429 0.85 CA2 (1.00) CA2CA12CA1CA9KMT2A
SCHEMBL8421687 0.85 CA2 (0.84) CA2CA12CA1CA9KMT2A
SCHEMBL671610 0.84 CA2 (1.00) CA2CA12CA1CA9KMT2A
SCHEMBL31310428 0.84 CA1 (0.74) CA2CA12CA1CA9KMT2A
SCHEMBL671546 0.84 CA2 (1.00) CA2CA12CA1CA9KMT2A
SCHEMBL15134184 0.84 KMT2A (0.85) CA2CA12CA1CA9KMT2A
SCHEMBL6692412 0.83 CA2 (0.76) CA2CA12CA1CA9KMT2A
SCHEMBL18095849 0.83 CA2 (1.00) CA2CA12CA1CA9KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130190396-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2013-07-25 US claimed
EP-2590938-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH Metasignal Therapeutics Inc. (CA) 2013-05-15 EP claimed
WO-2012021963-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2012-02-23 WO claimed
US-10398749-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2019-09-03 US disclosed
US-10398680-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2019-09-03 US disclosed
US-20190240195-A1 METHODS OF TREATING MUSCULAR DYSTROPHY Board of Regents of the Nevada System of Higher Education, on behalf of the Univ of Nevada, Reno (US) 2019-08-08 US disclosed
US-10272069-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2019-04-30 US disclosed
US-10206903-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2019-02-19 US disclosed
US-10028992-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2018-07-24 US disclosed
US-10028992-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2018-07-24 US disclosed
EP-2892525-B1 METHODS OF TREATING MUSCULAR DYSTROPHY UNIV NEVADA RENO (US) 2018-06-13 EP disclosed
US-20140072536-A1 METHODS OF TREATING MUSCULAR DYSTROPHY BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA (US) 2014-03-13 US disclosed
US-20130190396-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2013-07-25 US disclosed
EP-2590938-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH Metasignal Therapeutics Inc. (CA) 2013-05-15 EP disclosed
WO-2012021963-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2012-02-23 WO disclosed
WO-2012021963-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2012-02-23 WO disclosed
EP-1682143-A2 COMBINATIONS COMPRISING AN HSP90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA Pharmacia Corporation (US) 2006-07-26 EP disclosed
WO-2005044194-A2 TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR PHARMACIA CORPORATION (US) 2005-05-19 WO disclosed
WO-2005041879-A2 COMBINATIONS COMPRISING AN Hsp90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA PHARMACIA CORPORATION (US) 2005-05-12 WO disclosed
WO-2005041879-A2 COMBINATIONS COMPRISING AN Hsp90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA PHARMACIA CORPORATION (US) 2005-05-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10272069-B2 Methods of treating muscular dystrophy ITGB7, ITGA2B, ITGB1 CA2 3918/4885CA12 4545/4885CA1 4507/4885
US-10028992-B2 Methods of treating muscular dystrophy ITGB7, ITGA2B, ITGB1 CA2 3918/4885CA12 4545/4885CA1 4507/4885
US-10398680-B2 Methods of treating muscular dystrophy ITGB7, ITGA2B, ITGB1 CA2 3918/4885CA12 4545/4885CA1 4507/4885
US-10398749-B2 Methods of treating muscular dystrophy ITGB7, ITGA2B, ITGB1 CA2 3918/4885CA12 4545/4885CA1 4507/4885
US-20130190396-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH HIF1AN, CBX2, HIF1A CA2 5/4885CA12 61/4885CA1 31/4885
US-20190240195-A1 METHODS OF TREATING MUSCULAR DYSTROPHY ITGB7, ITGA2B, ITGB1 CA2 3918/4885CA12 4545/4885CA1 4507/4885
US-10206903-B2 Methods of treating muscular dystrophy ITGB7, ITGA2B, ITGB1 CA2 3918/4885CA12 4545/4885CA1 4507/4885
US-20140072536-A1 METHODS OF TREATING MUSCULAR DYSTROPHY ITGB7, ITGA2B, ITGB1 CA2 3918/4885CA12 4545/4885CA1 4507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.