SCHEMBL671590

SCHEMBL671590

CCCn1cc(I)cn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL177537 0.88 L3MBTL1 (0.41)
SCHEMBL2951930 0.86 L3MBTL1 (0.40)
SCHEMBL2384675 0.84 KDR (0.40)
SCHEMBL7338253 0.84 KDR (0.40)
SCHEMBL17943855 0.84 KDR (0.40)
SCHEMBL1581682 0.82
SCHEMBL27745988 0.79 L3MBTL1 (0.38)
SCHEMBL13672040 0.78
SCHEMBL3570927 0.78
SCHEMBL5901788 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116239577-A Method for preparing cudexestat 沈阳药科大学 2023-06-09 CN claimed
US-12421207-B2 Pyrimidinedione-based compounds as AXL, c-MET, and Mer inhibitors and methods of use thereof CMG PHARMACEUTICAL CO., LTD. (KR) 2025-09-23 US disclosed
US-20250171426-A1 PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF CMG PHARMACEUTICAL CO., LTD. (KR) 2025-05-29 US disclosed
CN-119591596-A 4, 5-Dihydro-3H-pyrrolo [2,3-c ] quinolin-4-one derivatives and uses thereof 沈阳药科大学 2025-03-11 CN disclosed
EP-4479397-A1 PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF CMG Pharmaceutical Co., Ltd. (KR) 2024-12-25 EP disclosed
CN-119032087-A Pyrimidinedione-based compounds as AXL, C-MET and MER inhibitors and methods of use thereof CMG制药株式会社 2024-11-26 CN disclosed
US-20230348423-A1 PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF CMG PHARMACEUTICAL CO., LTD. (KR) 2023-11-02 US disclosed
US-20230348423-A1 PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF CMG PHARMACEUTICAL CO., LTD. (KR) 2023-11-02 US disclosed
US-20230348423-A1 PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF CMG PHARMACEUTICAL CO., LTD. (KR) 2023-11-02 US disclosed
WO-2023156863-A1 PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF CMG PHARMACEUTICAL CO., LTD. (KR) 2023-08-24 WO disclosed
US-20160229809-A1 HETEROCYCLIC VINYL AUTOTAXIN INHIBITOR COMPOUNDS DF 2024 IP ACQUISITION, LLC 2016-08-11 US disclosed
EP-3046909-A1 HETEROCYCLIC VINYL AUTOTAXIN INHIBITOR COMPOUNDS Pharmakea Inc. (US) 2016-07-27 EP disclosed
US-20150164861-A1 AUTOTAXIN INHIBITORS AND USES THEREOF AMIRA PHARMACEUTICALS, INC. (US) 2015-06-18 US disclosed
US-9000025-B2 Autotaxin inhibitors and uses thereof AMIRA PHARMACEUTICALS, INC. (US) 2015-04-07 US disclosed
WO-2015042052-A1 HETEROCYCLIC VINYL AUTOTAXIN INHIBITOR COMPOUNDS PHARMAKEA, INC. (US) 2015-03-26 WO disclosed
US-20130324542-A1 [1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) 2013-12-05 US disclosed
EP-2650293-A1 [1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZINE COMPOUND, PREPARATION METHOD AND USE THEREOF Shanghai Institute Materia Medica, Chinese Academy Of Sciences (CN) 2013-10-16 EP disclosed
EP-2606031-A2 AUTOTAXIN INHIBITORS AND USES THEREOF Amira Pharmaceuticals, Inc. (US) 2013-06-26 EP disclosed
US-20130150326-A1 AUTOTAXIN INHIBITORS AND USES THEREOF AMIRA PHARMACEUTICALS, INC. (US) 2013-06-13 US disclosed
WO-2012024620-A2 AUTOTAXIN INHIBITORS AND USES THEREOF AMIRA PHARMACEUTICALS, INC. (US) 2012-02-23 WO disclosed