Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.55 |
| ▸ | HTR1D | P28221 | 10/20 | 0.55 |
| ▸ | HTR1B | P28222 | 10/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | HTR6 | P50406 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6718801 | 0.93 | HTR1A (0.65) | HTR1AHTR1DHTR1BMAPTRAB9A | |
| SCHEMBL6714750 | 0.92 | HTR1A (0.54) | HTR1AHTR1DHTR1BMAPTHTR2A | |
| SCHEMBL6717660 | 0.91 | HTR1A (0.64) | HTR1AHTR1DHTR1BMAPTRAB9A | |
| SCHEMBL6720400 | 0.87 | MAPT (0.58) | HTR1AHTR1DHTR1BMAPTRAB9A | |
| SCHEMBL6714894 | 0.87 | HTR1A (0.49) | HTR1AHTR1DHTR1BMAPTHTR2A | |
| SCHEMBL6718830 | 0.87 | SMN1; SMN2 (0.49) | HTR1AHTR1DHTR1BMAPTHTR2A | |
| SCHEMBL6714953 | 0.86 | CA12 (0.53) | HTR1AHTR1DHTR1BMAPTRAB9A | |
| SCHEMBL6716740 | 0.86 | HTR1A (0.54) | HTR1AHTR1DHTR1BMAPTHTT | |
| SCHEMBL6714774 | 0.86 | HTR1A (0.56) | HTR1AHTR1DHTR1BMAPTHTT | |
| SCHEMBL6716646 | 0.85 | HTR1A (0.64) | HTR1AHTR1DHTR1BMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313477-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-03 | — | — | EP | claimed |
| EP-1313477-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2003-05-28 | — | — | EP | claimed |
| WO-2002005819-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-24 | — | — | WO | claimed |
| EP-1313477-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-1313477-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002005819-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-24 | — | — | WO | disclosed |