Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6371565 | 0.89 | MEN1 (0.54) | MEN1KMT2ARAB9ANPC1HSD17B10 | |
| SCHEMBL6293636 | 0.89 | ROCK2 (0.60) | ROCK2CYP3A4ROCK1ALDH1A1MAPT | |
| SCHEMBL6299444 | 0.89 | ROCK2 (0.63) | MEN1KMT2ARAB9ANPC1ROCK2 | |
| SCHEMBL6293942 | 0.87 | KMT2A (0.64) | MEN1KMT2ARAB9ANPC1ROCK2 | |
| SCHEMBL8238838 | 0.85 | PLAU (0.58) | MEN1KMT2AROCK2CYP3A4NOD1 | |
| SCHEMBL7657010 | 0.85 | MEN1 (0.52) | MEN1KMT2ARAB9ANPC1ROCK2 | |
| SCHEMBL6298411 | 0.83 | TMPRSS2 (0.65) | MEN1KMT2ARAB9ANPC1ROCK2 | |
| SCHEMBL7802384 | 0.83 | MEN1 (0.58) | MEN1KMT2ARAB9ANPC1ROCK2 | |
| SCHEMBL6293583 | 0.80 | MAPT (0.59) | MEN1KMT2ARAB9ANPC1ROCK2 | |
| SCHEMBL6293954 | 0.80 | ROCK2 (0.77) | MEN1KMT2ARAB9ANPC1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040209912-A1 | Substituted isoquinoline derivatives and their use as anticonvulsants | SMITHKLINE BEECHAM P.L.C. | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209912-A1 | Substituted isoquinoline derivatives and their use as anticonvulsants | INA, GRIN2C, GRIN2A | MEN1 3408/4885KMT2A 445/4885RAB9A 1671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.