Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1856212 | 0.99 | SPHK1 (0.44) | SPHK1SPHK2ALDH1A1PPARGPPARD | |
| SCHEMBL1854299 | 0.93 | SPHK1 (0.43) | SPHK1SPHK2ALDH1A1PPARGPPARD | |
| SCHEMBL1857980 | 0.90 | SPHK1 (0.47) | SPHK1SPHK2ALDH1A1PPARGPPARD | |
| SCHEMBL1857829 | 0.90 | SPHK1 (0.47) | SPHK1SPHK2ALDH1A1PPARGPPARD | |
| SCHEMBL6725380 | 0.90 | SPHK1 (0.51) | SPHK1SPHK2ALDH1A1PPARGPPARD | |
| SCHEMBL1855183 | 0.90 | SPHK1 (0.51) | SPHK1SPHK2ALDH1A1PPARGPPARD | |
| Hydrochloric Acid SCHEMBL1855130 | 0.89 | SPHK1 (0.50) | SPHK1SPHK2ALDH1A1PPARGPPARD | |
| SCHEMBL1854919 | 0.86 | SPHK1 (0.42) | SPHK1SPHK2ALDH1A1PPARGPPARD | |
| SCHEMBL1858451 | 0.86 | SPHK1 (0.41) | SPHK1SPHK2ALDH1A1NPC1RAB9A | |
| SCHEMBL1856445 | 0.86 | ALDH1A1 (0.53) | SPHK1SPHK2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | disclosed |