Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 7/20 | 0.41 |
| ▸ | MMP9 | P14780 | 7/20 | 0.41 |
| ▸ | MMP13 | P45452 | 5/20 | 0.41 |
| ▸ | MMP1 | P03956 | 4/20 | 0.41 |
| ▸ | MMP3 | P08254 | 3/20 | 0.41 |
| ▸ | MMP14 | P50281 | 3/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | MMP16 | P51512 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6719663 | 0.87 | DUT (0.56) | DUTLMNAMMP2MMP9MMP13 | |
| SCHEMBL6723951 | 0.86 | DUT (0.54) | DUTLMNAMMP2MMP9MMP13 | |
| SCHEMBL6722436 | 0.85 | DUT (0.53) | DUTLMNAMMP2MMP9MMP13 | |
| SCHEMBL6723955 | 0.85 | DUT (0.55) | DUTLMNAMMP2MMP9MMP13 | |
| SCHEMBL6719102 | 0.83 | DUT (0.51) | DUTLMNAMMP2MMP9MMP13 | |
| SCHEMBL6722422 | 0.83 | DUT (0.53) | DUTLMNAMMP2MMP9MMP13 | |
| SCHEMBL6719278 | 0.82 | DUT (0.56) | DUTLMNAMMP2MMP9MMP13 | |
| SCHEMBL6724138 | 0.81 | DUT (0.55) | DUTLMNAMMP2MMP9MMP13 | |
| SCHEMBL6726788 | 0.80 | DUT (0.51) | DUTLMNAMMP2MMP9MMP13 | |
| SCHEMBL6731210 | 0.80 | DUT (0.51) | DUTLMNAMMP2MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |