Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6722438 | 0.79 | ATM (0.38) | DUTNPC1ALDH1A1CYP3A4HPGD | |
| SCHEMBL6723774 | 0.78 | NPC1 (0.37) | DUTNPC1ALDH1A1CYP3A4HPGD | |
| SCHEMBL25344963 | 0.77 | NPC1 (0.35) | DUTNPC1ALDH1A1CYP3A4HPGD | |
| SCHEMBL23320065 | 0.77 | HPGD (0.48) | NPC1ALDH1A1HPGDPOLBMAPT | |
| SCHEMBL6727003 | 0.76 | NPC1 (0.37) | DUTNPC1ALDH1A1CYP3A4HPGD | |
| SCHEMBL25343757 | 0.75 | NPC1 (0.38) | NPC1ALDH1A1CYP3A4HPGDMAPT | |
| SCHEMBL25344725 | 0.75 | NPC1 (0.38) | DUTNPC1ALDH1A1MAPTKMT2A | |
| SCHEMBL25346003 | 0.75 | NPC1 (0.36) | DUTNPC1ALDH1A1CYP3A4HPGD | |
| SCHEMBL6719796 | 0.74 | DUT (0.37) | DUTNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL6726798 | 0.74 | NPC1 (0.40) | DUTNPC1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |