SCHEMBL6719952

SCHEMBL6719952

CCCCCCCCCCCc1noc(-c2cccc(C[N+]([O-])(CC)Cc3ccccc3C(F)(F)F)c2)n1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SPHK1 Q9NYA1 8/20 0.39
SPHK2 Q9NRA0 7/20 0.39
ALDH1A1 P00352 2/20 0.39
HPGD P15428 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38
MAPT P10636 1/20 0.38
PKM P14618 1/20 0.38
RAB9A P51151 1/20 0.38
HSD17B10 Q99714 1/20 0.38
CHRM2 P08172 3/20 0.35
CHRM4 P08173 3/20 0.35
CHRM5 P08912 3/20 0.35
CHRM1 P11229 3/20 0.35
CHRM3 P20309 3/20 0.35
S1PR1 P21453 1/20 0.34
PPARG P37231 1/20 0.32
PPARD Q03181 1/20 0.32
PPARA Q07869 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6718594 0.90 SMN1; SMN2 (0.42) SPHK1SPHK2ALDH1A1HPGDSMN1; SMN2
SCHEMBL6715222 0.88 SPHK2 (0.41) SPHK1SPHK2ALDH1A1HPGDSMN1; SMN2
SCHEMBL1855933 0.83 SPHK1 (0.36) SPHK1SPHK2ALDH1A1HPGDSMN1; SMN2
SCHEMBL5046496 0.83 SPHK1 (0.41) SPHK1SPHK2ALDH1A1HPGDSMN1; SMN2
SCHEMBL5048811 0.83 SPHK1 (0.42) SPHK1SPHK2ALDH1A1HPGDSMN1; SMN2
SCHEMBL1858451 0.82 SPHK1 (0.41) SPHK1SPHK2ALDH1A1HPGDSMN1; SMN2
SCHEMBL6823058 0.82 ALDH1A1 (0.40) SPHK1SPHK2ALDH1A1HPGDSMN1; SMN2
SCHEMBL6823315 0.81 ALDH1A1 (0.39) SPHK1SPHK2ALDH1A1HPGDSMN1; SMN2
SCHEMBL1857249 0.77 PPARG (0.42) SPHK1SPHK2ALDH1A1HPGDSMN1; SMN2
SCHEMBL1852681 0.77 SPHK1 (0.42) SPHK1SPHK2ALDH1A1HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1470102-A1 SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) Applied Research Systems ARS Holding N.V. (AN) 2004-10-27 EP disclosed
WO-2003064376-A1 SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2003-08-07 WO disclosed