Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.71 |
| ▸ | MITF | O75030 | 5/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.71 |
| ▸ | RAD52 | P43351 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | HTT | P42858 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | CCR6 | P51684 | 1/20 | 0.59 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.59 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | APAF1 | O14727 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5896273 | 0.93 | MAPK1 (0.68) | MAPK1MITFKDM4ERAD52KMT2A | |
| SCHEMBL5896261 | 0.93 | MAPK1 (0.68) | MAPK1MITFKDM4ERAD52KMT2A | |
| SCHEMBL5896285 | 0.93 | MAPK1 (0.68) | MAPK1MITFKDM4ERAD52KMT2A | |
| SCHEMBL5895812 | 0.81 | MAPT (0.67) | MAPK1MITFKDM4ERAD52KMT2A | |
| SCHEMBL5895791 | 0.81 | MAPT (0.67) | MAPK1MITFKDM4ERAD52KMT2A | |
| SCHEMBL5895805 | 0.81 | MAPT (0.67) | MAPK1MITFKDM4ERAD52KMT2A | |
| SCHEMBL5896010 | 0.79 | MAPT (0.65) | MAPK1MITFKDM4ERAD52KMT2A | |
| SCHEMBL5896030 | 0.79 | MAPT (0.65) | MAPK1MITFKDM4ERAD52KMT2A | |
| SCHEMBL5896020 | 0.79 | MAPT (0.65) | MAPK1MITFKDM4ERAD52KMT2A | |
| SCHEMBL5896582 | 0.76 | MAPT (0.56) | MAPK1MITFKDM4ERAD52KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183236-B2 | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-05-22 | — | — | US | disclosed |
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | TYMP, IMPDH1, SAMHD1 | MAPK1 966/4885MITF 4321/4885KDM4E 1795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.