Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856884 | 0.84 | FFAR1 (0.47) | PYCR1KCNH2FFAR1FFAR4 | |
| SCHEMBL1857109 | 0.84 | FFAR1 (0.38) | KDM4ELMNAFFAR1FFAR4 | |
| SCHEMBL1853689 | 0.82 | SCN8A (0.37) | LMNAGAAKCNH2FFAR1FFAR4 | |
| SCHEMBL1855158 | 0.81 | FFAR1 (0.34) | KDM4EGAANPSR1FFAR1FFAR4 | |
| SCHEMBL5044384 | 0.79 | PTGES2 (0.33) | KCNH2FFAR1FFAR4 | |
| SCHEMBL1855159 | 0.77 | FFAR1 (0.34) | SMN1; SMN2FFAR1FFAR4 | |
| SCHEMBL6824407 | 0.75 | CYP3A4 (0.35) | KDM4EPYCR1KCNH2FFAR1FFAR4 | |
| SCHEMBL1852603 | 0.75 | CYP3A4 (0.35) | KDM4EPYCR1KCNH2FFAR1FFAR4 | |
| SCHEMBL1850743 | 0.73 | KCNH2 (0.49) | KDM4ELMNAKCNH2 | |
| SCHEMBL1853423 | 0.73 | KCNH2 (0.44) | KDM4ELMNAPYCR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | disclosed |