Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 2/20 | 0.30 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044417 | 0.84 | FFAR1 (0.47) | KCNH2FFAR1FFAR4FFAR2PPARG | |
| SCHEMBL5046558 | 0.84 | FFAR1 (0.47) | KCNH2FFAR1FFAR4FFAR2PPARG | |
| SCHEMBL5047701 | 0.84 | FFAR1 (0.47) | KCNH2FFAR1FFAR4FFAR2PPARG | |
| SCHEMBL1853689 | 0.81 | SCN8A (0.37) | PTGES2KCNH2FFAR1FFAR4PPARG | |
| SCHEMBL6720907 | 0.79 | KDM4E (0.35) | KCNH2FFAR1FFAR4 | |
| SCHEMBL5044094 | 0.75 | CYP3A4 (0.38) | KCNH2 | |
| SCHEMBL1855159 | 0.75 | FFAR1 (0.34) | FFAR1FFAR4PPARGPPARDPPARA | |
| SCHEMBL5045784 | 0.75 | — | — | |
| SCHEMBL5044913 | 0.75 | HTR2A (0.43) | — | |
| SCHEMBL1857109 | 0.74 | FFAR1 (0.38) | FFAR1FFAR4PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |