Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.98 |
| ▸ | POLB | P06746 | 9/20 | 0.98 |
| ▸ | GAA | P10253 | 7/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.98 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.98 |
| ▸ | RAB9A | P51151 | 4/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.98 |
| ▸ | G6PD | P11413 | 1/20 | 0.98 |
| ▸ | HTT | P42858 | 1/20 | 0.98 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | NSD2 | O96028 | 1/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | LDHA | P00338 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6721120 | 0.81 | MAPT (0.71) | MAPTKDM4EPOLBGAAALDH1A1 | |
| SCHEMBL6721119 | 0.75 | KDM4E (0.69) | MAPTKDM4EPOLBGAAALDH1A1 | |
| SCHEMBL19420133 | 0.74 | MAPT (0.76) | MAPTKDM4EPOLBALDH1A1L3MBTL1 | |
| SCHEMBL6721172 | 0.74 | MAPT (0.78) | MAPTKDM4EPOLBGAAALDH1A1 | |
| SCHEMBL6721165 | 0.73 | KDM4E (0.66) | MAPTKDM4EPOLBGAAALDH1A1 | |
| SCHEMBL6420380 | 0.72 | BIRC5 (0.70) | MAPTKDM4EPOLBGAAALDH1A1 | |
| SCHEMBL6420375 | 0.72 | BIRC5 (0.70) | MAPTKDM4EPOLBGAAALDH1A1 | |
| SCHEMBL6721123 | 0.71 | MAPT (0.58) | MAPTKDM4EPOLBGAAALDH1A1 | |
| SCHEMBL6721129 | 0.71 | MAPT (0.65) | MAPTKDM4EPOLBGAAALDH1A1 | |
| SCHEMBL6721168 | 0.70 | MAPT (0.68) | MAPTKDM4EPOLBGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183236-B2 | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183236-B2 | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-05-22 | — | — | US | disclosed |
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-04-02 | — | — | US | disclosed |
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | TYMP, IMPDH1, SAMHD1 | MAPT 2174/4885KDM4E 1795/4885POLB 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.