⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106917 | 0.65 | — | — | |
| SCHEMBL4933630 | 0.65 | — | — | |
| SCHEMBL448317 | 0.65 | — | — | |
| SCHEMBL558752 | 0.65 | — | — | |
| SCHEMBL451629 | 0.65 | — | — | |
| SCHEMBL17474307 | 0.65 | — | — | |
| SCHEMBL450465 | 0.65 | — | — | |
| SCHEMBL9170 | 0.65 | — | — | |
| SCHEMBL3278665 | 0.64 | — | — | |
| SCHEMBL4931800 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 293 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423357-B1 | UREA DERIVATIVES WITH ANTIPROTEOLYTIC ACTIVITY | SANOFI AVENTIS DEUTSCHLAND (DE) | 2006-09-06 | — | — | EP | claimed |
| EP-1423357-A2 | UREA DERIVATIVES WITH ANTIPROTEOLYTIC ACTIVITY | Aventis Pharma Deutschland GmbH (DE) | 2004-06-02 | — | — | EP | claimed |
| US-6706715-B2 | REVERSIBLE INHIBITORS OF THE BLOOD CLOTTING ENZYME FACTOR VIIA | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-03-16 | — | — | US | claimed |
| US-6646010-B2 | Enzyme inhibitors such as N(3-benzyloxycarbonylamino-2-hydroxy -4-phenylbutyl)-N-isoamylamine, used for prophylaxis of viral diseases and infections; lymphadenopathy associated virus | G. D. SEARLE & CO. | 2003-11-11 | — | — | US | claimed |
| US-20030199527-A1 | Use of corticotropin releasing factor antagonists and related compositions | HAMANAKA ERNEST S (US) | 2003-10-23 | — | — | US | claimed |
| US-20030176439-A1 | Urea derivatives with antiproteolytic activity | AVENTIS PHARMA DUTSCHLAND GMBH | 2003-09-18 | — | — | US | claimed |
| EP-1293213-A1 | PREVENTIVES/REMEDIES FOR POSTOPERATIVE STRESS | JAPAN TOBACCO INC. (JP) | 2003-03-19 | — | — | EP | claimed |
| WO-2003002524-A2 | UREA DERIVATIVES WITH ANTIPROTEOLYTIC ACTIVITY | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-01-09 | — | — | WO | claimed |
| EP-0691128-B1 | Use of CRF antagonists | PFIZER (US) | 2002-12-11 | — | — | EP | claimed |
| US-6403599-B1 | STROKE, HYPERTENSION, TACHYCARDIA, AND CONGESTIVE HEART FAILURE, OSTEOPOROSIS, PREMATURE BIRTH, PSYCHOSOCIAL DWARFISM, STRESS-INDUCED FEVER, ULCER, DIARRHEA, POST-OPERATIVE ILEUS, AND COLONIC HYPERSENSITIVITY, CARDIOVASCULAR DISORDERS | PFIZER INC | 2002-06-11 | — | — | US | claimed |
| EP-0773023-A1 | New uses for corticotropin releasing factor (CRF) antagonists | PFIZER INC. (US) | 1997-05-14 | — | — | EP | claimed |
| EP-0764153-A1 | SUBSTITUTED PYRAZOLES HAVING CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1997-03-26 | — | — | EP | claimed |
| EP-0691128-A1 | Methods of administering CRF antagonists | PFIZER INC. (US) | 1996-01-10 | — | — | EP | claimed |
| WO-1995033727-A1 | SUBSTITUTED PYRAZOLES HAVING CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1995-12-14 | — | — | WO | claimed |
| EP-0674642-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | claimed |
| EP-0674625-A1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER INC. (US) | 1995-10-04 | — | — | EP | claimed |
| EP-0674624-A1 | PYRAZOLES AND PYRAZOLOPYRIMIDINES HAVING CRF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1995-10-04 | — | — | EP | claimed |
| WO-1994013643-A1 | PYRAZOLES AND PYRAZOLOPYRIMIDINES HAVING CRF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1994-06-23 | — | — | WO | claimed |
| WO-1994013644-A1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER INC. (US) | 1994-06-23 | — | — | WO | claimed |
| WO-1994013677-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | claimed |