Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.62 |
| ▸ | KDR | P35968 | 4/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.62 |
| ▸ | FLT4 | P35916 | 2/20 | 0.62 |
| ▸ | BRAF | P15056 | 2/20 | 0.62 |
| ▸ | CIT | O14578 | 2/20 | 0.62 |
| ▸ | GAK | O14976 | 2/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.62 |
| ▸ | STK17B | O94768 | 2/20 | 0.62 |
| ▸ | STK10 | O94804 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
| ▸ | LYN | P07948 | 2/20 | 0.62 |
| ▸ | RET | P07949 | 2/20 | 0.62 |
| ▸ | MET | P08581 | 2/20 | 0.62 |
| ▸ | HCK | P08631 | 2/20 | 0.62 |
| ▸ | FGR | P09769 | 2/20 | 0.62 |
| ▸ | KIT | P10721 | 2/20 | 0.62 |
| ▸ | SRC | P12931 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31491127 | 0.83 | SRC (0.53) | EGFRKDRERBB2FLT4BRAF | |
| SCHEMBL13319080 | 0.81 | EGFR (0.71) | EGFRKDRERBB2FLT4BRAF | |
| SCHEMBL4422710 | 0.80 | SRC (0.65) | EGFRKDRERBB2FLT4BRAF | |
| SCHEMBL29540227 | 0.80 | SRC (0.65) | EGFRKDRERBB2FLT4BRAF | |
| SCHEMBL4428694 | 0.80 | SRC (0.65) | EGFRKDRERBB2FLT4BRAF | |
| SCHEMBL28713534 | 0.80 | EGFR (0.92) | EGFRKDRERBB2FLT4BRAF | |
| SCHEMBL29577833 | 0.80 | EGFR (0.92) | EGFRKDRERBB2FLT4BRAF | |
| SCHEMBL28969386 | 0.79 | SRC (0.50) | EGFRKDRERBB2FLT4BRAF | |
| SCHEMBL19612073 | 0.79 | EGFR (0.86) | EGFRKDRERBB2FLT4BRAF | |
| SCHEMBL4597943 | 0.79 | EGFR (0.66) | EGFRKDRERBB2CITGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605650-A2 | COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL AND DIACETYLDIANHYDROGALACTITOL | Del Mar Pharmaceuticals (CA) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024367-A2 | COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL AND DIACETYLDIANHYDROGALACTITOL | DEL MAR PHARMACEUTICALS (CA) | 2012-02-23 | — | — | WO | disclosed |