Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.33 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.33 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.33 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.33 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311 | 0.88 | LPAR1 (0.41) | FFAR4CYP2C9LPAR1ABCC3ABCC4 | |
| SCHEMBL6861 | 0.85 | LPAR1 (0.42) | FFAR4CYP2C9LPAR1ABCC3ABCC4 | |
| SCHEMBL6722 | 0.84 | HDAC6 (0.36) | FFAR4CYP2C9LPAR1ABCC3ABCC4 | |
| SCHEMBL3678 | 0.82 | LPAR1 (0.37) | FFAR4CYP2C9LPAR1ABCC3ABCC4 | |
| SCHEMBL3972 | 0.81 | LPAR1 (0.38) | FFAR4CYP2C9LPAR1ABCC3ABCC4 | |
| SCHEMBL7443 | 0.81 | SLC6A9 (0.40) | FFAR4CYP2C9LPAR1ABCC3ABCC4 | |
| SCHEMBL6482 | 0.79 | LPAR1 (0.41) | FFAR4CYP2C9LPAR1ABCC3ABCC4 | |
| SCHEMBL7310 | 0.76 | LPAR1 (0.39) | CYP2C9LPAR1ABCC3ABCC4ABCB11 | |
| SCHEMBL7143 | 0.76 | LPAR1 (0.41) | FFAR4CYP2C9LPAR1ABCC3ABCC4 | |
| SCHEMBL6977 | 0.75 | LPAR1 (0.41) | FFAR4CYP2C9LPAR1ABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |