Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | GBA1 | P04062 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | PPP5C | P53041 | 2/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | PPM1B | O75688 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6723339 | 1.00 | TSHR (0.59) | TSHRGBA1KDM4EGMNNLMNA | |
| SCHEMBL15796345 | 0.84 | TSHR (0.68) | TSHRGBA1KDM4EGMNNLMNA | |
| SCHEMBL1665130 | 0.81 | TSHR (0.65) | TSHRKDM4EGMNNLMNAPMP22 | |
| Hydrochloric Acid SCHEMBL9445206 | 0.81 | TSHR (0.65) | TSHRKDM4EGMNNLMNAPMP22 | |
| SCHEMBL7827217 | 0.81 | TSHR (0.65) | TSHRKDM4EGMNNLMNAPMP22 | |
| SCHEMBL14972599 | 0.77 | TSHR (0.59) | TSHRKDM4EGMNNLMNAPMP22 | |
| SCHEMBL6796708 | 0.75 | TSHR (0.41) | TSHRPPP5CPPM1BPTPN1PPP1CC | |
| SCHEMBL6796704 | 0.75 | TSHR (0.41) | TSHRPPP5CPPM1BPTPN1PPP1CC | |
| SCHEMBL1663988 | 0.72 | TSHR (0.48) | TSHRKDM4EGMNNLMNAPMP22 | |
| SCHEMBL1663194 | 0.72 | TFPI2 (0.50) | TSHRKDM4EGMNNLMNAPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040242897-A1 | Universal support media for synthesis of oligomeric compounds | ISIS PHARMACEUTICALS, INC. | 2004-12-02 | — | — | US | disclosed |
| US-20040152905-A1 | Universal building blocks and support media for synthesis of oligonucleotides and their analogs | ISIS PHARMACEUTICALS, INC. | 2004-08-05 | — | — | US | disclosed |
| US-6653468-B1 | Bicyclic heptane derivatives linked to controlled pore glass or copolymers of polystyrene; can be cleaved and used for subsequent reactions | ISIS PHARMACEUTICALS, INC. | 2003-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152905-A1 | Universal building blocks and support media for synthesis of oligonucleotides and their analogs | POLM, POLRMT, POLB | TSHR 3397/4885GBA1 3140/4885KDM4E 4608/4885 |
| US-20040242897-A1 | Universal support media for synthesis of oligomeric compounds | NEFM, POLRMT, POLM | TSHR 4495/4885GBA1 3292/4885KDM4E 4570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.