Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 8/20 | 0.74 |
| ▸ | KDR | P35968 | 7/20 | 0.59 |
| ▸ | BRAF | P15056 | 3/20 | 0.58 |
| ▸ | CDK8 | P49336 | 2/20 | 0.58 |
| ▸ | CA7 | P43166 | 2/20 | 0.58 |
| ▸ | CA9 | Q16790 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | CIT | O14578 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | MUSK | O15146 | 1/20 | 0.58 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.58 |
| ▸ | MLNR | O43193 | 1/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.58 |
| ▸ | PDE6D | O43924 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21955644 | 0.90 | RAF1 (0.64) | RAF1KDRBRAFCDK8CA7 | |
| Water SCHEMBL3841018 | 0.90 | RAF1 (0.63) | RAF1KDRBRAFCDK8CA7 | |
| SCHEMBL29918250 | 0.85 | RAF1 (1.00) | RAF1KDRBRAFCDK8CA7 | |
| SCHEMBL548133 | 0.85 | RAF1 (1.00) | RAF1KDRBRAFCDK8CA7 | |
| SCHEMBL16621032 | 0.83 | RAF1 (0.52) | RAF1MEN1AURKARPS6KB1KMT2A | |
| SCHEMBL3790500 | 0.81 | KDR (0.64) | RAF1KDRBRAFCDK8CA7 | |
| SCHEMBL3766220 | 0.81 | RAF1 (0.48) | RAF1KDRBRAF | |
| SCHEMBL4238109 | 0.80 | RAF1 (0.82) | RAF1KDRBRAFCDK8CA7 | |
| SCHEMBL171199 | 0.80 | RAF1 (0.81) | RAF1KDRBRAFCDK8CA7 | |
| SCHEMBL939087 | 0.80 | RAF1 (0.85) | RAF1KDRBRAFCDK8CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632458-A1 | DOSING REGIMES FOR THE TREATMENT OF OCULAR VASCULAR DISEASE | Novartis AG (CH) | 2013-09-04 | — | — | EP | disclosed |
| EP-2605650-A2 | COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL AND DIACETYLDIANHYDROGALACTITOL | Del Mar Pharmaceuticals (CA) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012055884-A1 | DOSING REGIMES FOR THE TREATMENT OF OCULAR VASCULAR DISEASE | NOVARTIS AG (CH) | 2012-05-03 | — | — | WO | disclosed |
| WO-2012024367-A2 | COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL AND DIACETYLDIANHYDROGALACTITOL | DEL MAR PHARMACEUTICALS (CA) | 2012-02-23 | — | — | WO | disclosed |