Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6012882 | 0.85 | RAF1 (0.66) | RAF1KDRBRAF | |
| SCHEMBL672388 | 0.81 | RAF1 (0.74) | RAF1KDRBRAF | |
| SCHEMBL27576013 | 0.80 | RAF1 (0.59) | RAF1GRM4KDRBRAF | |
| SCHEMBL16621032 | 0.78 | RAF1 (0.52) | RAF1CYP4F2CYP4A11 | |
| SCHEMBL4246399 | 0.76 | HTR3E (0.49) | GRM4S1PR1IDO1KDR | |
| SCHEMBL694648 | 0.76 | RAF1 (0.67) | RAF1KDRBRAF | |
| SCHEMBL13727752 | 0.76 | RAF1 (0.54) | RAF1GRM4KDRBRAF | |
| SCHEMBL16143280 | 0.75 | RAF1 (0.68) | RAF1KDRBRAF | |
| SCHEMBL27734542 | 0.75 | HTR3E (0.43) | GRM4S1PR1IDO1KDR | |
| SCHEMBL3766222 | 0.75 | RAF1 (0.44) | RAF1KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9545410-B2 | Tyrosine kinase inhibitors as anti-kinetoplastid agents | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2017-01-17 | — | — | US | disclosed |
| US-20130072484-A1 | TYROSINE KINASE INHIBITORS AS ANTI-KINETOPLASTID AND ANTI-APICOMPLEXAN AGENTS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2013-03-21 | — | — | US | disclosed |
| US-8338433-B2 | Tyrosine kinase inhibitors as anti-kinetoplastid agents | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20100311742-A1 | TYROSINE KINASE INHIBITORS AS ANTI-KINETOLASTID AND ANTI-APICOMPLEXAN AGENTS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2010-12-09 | — | — | US | disclosed |
| EP-2088863-A2 | TYROSINE KINASE INHIBITORS AS ANTI-KINETOLASTID AND ANTI-APICOMPLEXAN AGENTS | University Of Georgia Research Foundation, Inc. (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008066755-A2 | TYROSINE KINASE INHIBITORS AS ANTI-KINETOLASTID AND ANTI-APICOMPLEXAN AGENTS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2008-06-05 | — | — | WO | disclosed |