Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.58 |
| ▸ | MRGPRX4 | Q96LA9 | 11/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.51 |
| ▸ | RELA | Q04206 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4269670 | 0.87 | MEN1 (0.63) | SRD5A2SMN1; SMN2MEN1HPGDKMT2A | |
| SCHEMBL4265967 | 0.85 | F2 (0.49) | MRGPRX4TP53NFKB1NFKB2RELA | |
| SCHEMBL4267556 | 0.82 | NR4A2 (0.64) | MRGPRX4MEN1KMT2AALKBH1NR4A2 | |
| SCHEMBL4271200 | 0.82 | MRGPRX4 (0.59) | MRGPRX4SMN1; SMN2RAB9AMEN1NPC1 | |
| SCHEMBL4275299 | 0.82 | MAOB (0.53) | MRGPRX4TP53NFKB1NFKB2RELA | |
| SCHEMBL6721220 | 0.82 | RXRA (0.64) | MRGPRX4TP53NFKB1NFKB2RELA | |
| SCHEMBL4265055 | 0.80 | MRGPRX4 (0.64) | MRGPRX4TP53NFKB1NFKB2RELA | |
| SCHEMBL4265977 | 0.80 | MRGPRX4 (0.56) | MRGPRX4RAB9AMEN1NPC1KMT2A | |
| SCHEMBL4280714 | 0.79 | NR4A2 (0.67) | MRGPRX4NR4A2 | |
| SCHEMBL4266677 | 0.79 | FFAR1 (0.54) | MRGPRX4MEN1KMT2AALKBH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | claimed |
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2003009871-A2 | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR FOR DECREASING BODY MASS | GENSET S.A. (FR) | 2003-02-06 | — | — | WO | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |