SCHEMBL6725262

SCHEMBL6725262

C#Cc1ccc2[nH]c(S(=O)(=O)N3CCN(C(=O)c4ncc5c([n+]4[O-])CCc4cnccc4-5)CC3)cc2c1

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 9/20 0.37
KLK1 P06870 1/20 0.37
LMNA P02545 1/20 0.32
HRH4 Q9H3N8 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.31
ATM Q13315 1/20 0.31
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6734770 0.89 F10 (0.48) F10KLK1LMNAHRH4
SCHEMBL6725258 0.87 F10 (0.37) F10KLK1LMNAHRH4SMN1; SMN2
SCHEMBL6730434 0.84 F10 (0.39) F10KLK1LMNAHRH4SMN1; SMN2
SCHEMBL6728739 0.83 F10 (0.46) F10KLK1LMNAHRH4SMN1; SMN2
SCHEMBL6734766 0.77 F10 (0.48) F10KLK1LMNAHRH4
SCHEMBL6729599 0.74 F10 (0.46) F10KLK1HRH4
SCHEMBL6730108 0.73 F10 (0.54) F10KLK1ATM
SCHEMBL6729560 0.73 F10 (0.48) F10
SCHEMBL6729039 0.72 F10 (0.51) F10KLK1HRH4
SCHEMBL6733627 0.72 F10 (0.61) F10KLK1LMNAHRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6747023-B1 INHIBITORS FOR ACTIVATED COAGULATION FACTOR X, COAGULATION SUPPRESSORS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-06-08 US disclosed
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-29 US disclosed
EP-1104754-A1 NOVEL SULFONYL DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2001-06-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction F2, CYC1, SULT2A1 F10 19/4885KLK1 3139/4885LMNA 1760/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.