Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | PLA2G4B | P0C869 | 5/20 | 0.54 |
| ▸ | RARB | P10826 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25788122 | 1.00 | PLA2G2A (0.64) | PLA2G2ATP53TSHRESR1PLA2G4B | |
| SCHEMBL25788119 | 1.00 | PLA2G2A (0.64) | PLA2G2ATP53TSHRESR1PLA2G4B | |
| SCHEMBL25788117 | 1.00 | PLA2G2A (0.64) | PLA2G2ATP53TSHRESR1PLA2G4B | |
| SCHEMBL25788113 | 1.00 | PLA2G2A (0.64) | PLA2G2ATP53TSHRESR1PLA2G4B | |
| SCHEMBL25789856 | 0.91 | PLA2G2A (0.57) | PLA2G2ATP53TSHRESR1PLA2G4B | |
| SCHEMBL6725404 | 0.84 | TPMT (0.45) | PLA2G2ATSHRALDH1A1THRATHRB | |
| SCHEMBL1200906 | 0.82 | PLA2G2A (0.66) | PLA2G2ATP53TSHRPLA2G4BRARB | |
| SCHEMBL1108059 | 0.82 | PLA2G2A (0.66) | PLA2G2ATP53TSHRPLA2G4BRARB | |
| SCHEMBL318045 | 0.82 | PLA2G2A (0.66) | PLA2G2ATP53TSHRPLA2G4BRARB | |
| SCHEMBL1200970 | 0.82 | PLA2G2A (0.66) | PLA2G2ATP53TSHRPLA2G4BRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2003009871-A2 | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR FOR DECREASING BODY MASS | GENSET S.A. (FR) | 2003-02-06 | — | — | WO | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |