SCHEMBL6725848

SCHEMBL6725848

Cc1cc(-c2ccc(C(=O)N3CCN(S(=O)(=O)c4[nH]c5ccc(Cl)cc5c4O)CC3)cc2)cc[n+]1[O-]

nearest known ligand 0.47

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
F10 P00742 11/20 0.47
KLK1 P06870 1/20 0.47
MAP2 P11137 1/20 0.41
JAK2 O60674 2/20 0.41
BTK Q06187 2/20 0.41
JAK1 P23458 1/20 0.41
TYK2 P29597 1/20 0.41
JAK3 P52333 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
POLB P06746 1/20 0.38
HSP90AA1 P07900 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6733956 0.90 F10 (0.47) F10KLK1MAP2JAK2BTK
SCHEMBL6730713 0.90 F10 (0.46) F10KLK1MAP2JAK2BTK
SCHEMBL6729605 0.90 F10 (0.44) F10KLK1MAP2JAK2BTK
SCHEMBL6734925 0.88 F10 (0.45) F10KLK1MAP2JAK2BTK
SCHEMBL6730702 0.88 F10 (0.39) F10KLK1KMT2A
SCHEMBL6726146 0.88 F10 (0.46) F10KLK1MAP2JAK2BTK
SCHEMBL6729142 0.85 F10 (0.66) F10KLK1
SCHEMBL6730891 0.83 F10 (0.51) F10KLK1MAP2MEN1KMT2A
SCHEMBL6733162 0.82 F10 (0.49) F10KLK1MEN1KMT2A
SCHEMBL6733159 0.80 F10 (0.49) F10KLK1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6747023-B1 INHIBITORS FOR ACTIVATED COAGULATION FACTOR X, COAGULATION SUPPRESSORS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-06-08 US disclosed
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-29 US disclosed
EP-1104754-A1 NOVEL SULFONYL DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2001-06-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction F2, CYC1, SULT2A1 F10 19/4885KLK1 3139/4885MAP2 3780/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.