Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.45 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 8/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820556 | 0.83 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4ENPC1MAPT | |
| SCHEMBL27619399 | 0.83 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4ENPC1MAPT | |
| SCHEMBL3141291 | 0.83 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4ENPC1MAPT | |
| SCHEMBL2095926 | 0.83 | SPHK2 (0.54) | ALDH1A1HPGDKDM4ENPC1MAPT | |
| SCHEMBL1858819 | 0.81 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4ENPC1MAPT | |
| SCHEMBL94738 | 0.80 | SPHK2 (0.57) | ALDH1A1HPGDKDM4ENPC1MAPT | |
| SCHEMBL94737 | 0.80 | SPHK2 (0.54) | ALDH1A1HPGDKDM4ENPC1MAPT | |
| SCHEMBL16572028 | 0.79 | PPARA (0.55) | ALDH1A1HPGDKDM4ENPC1MAPT | |
| SCHEMBL11361627 | 0.78 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4ENPC1MAPT | |
| SCHEMBL1856445 | 0.77 | ALDH1A1 (0.53) | ALDH1A1HPGDKDM4ENPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100410236-C | Substituted methylene amide derivatives as protein tyrosine phosphatase modulators | APPLIED RESEARCH SYSTEMS (CH) | 2008-08-13 | — | — | CN | claimed |
| CN-1933827-A | Use of methylene amide derivatives in cardiovascular disorders | APPLIED RESEARCH SYSTEMS (AN) | 2007-03-21 | — | — | CN | claimed |
| CN-1633410-A | Substituted methylene amide derivatives as protein tyrosine phosphatase modulators | APPLIED RESEARCH SYSTEMS (AN) | 2005-06-29 | — | — | CN | claimed |
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | claimed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | claimed |
| CN-1933827-B | Use of methylene amide derivatives in preparing medicine for treating and/ or preventing heart failure | SERONO LAB | 2011-07-27 | — | — | CN | disclosed |
| CN-100410236-C | Substituted methylene amide derivatives as protein tyrosine phosphatase modulators | APPLIED RESEARCH SYSTEMS (CH) | 2008-08-13 | — | — | CN | disclosed |
| CN-1933827-A | Use of methylene amide derivatives in cardiovascular disorders | APPLIED RESEARCH SYSTEMS (AN) | 2007-03-21 | — | — | CN | disclosed |
| CN-1633410-A | Substituted methylene amide derivatives as protein tyrosine phosphatase modulators | APPLIED RESEARCH SYSTEMS (AN) | 2005-06-29 | — | — | CN | disclosed |