Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 17/20 | 0.67 |
| ▸ | MMP2 | P08253 | 9/20 | 0.67 |
| ▸ | MMP1 | P03956 | 11/20 | 0.53 |
| ▸ | MMP13 | P45452 | 10/20 | 0.53 |
| ▸ | MMP14 | P50281 | 4/20 | 0.53 |
| ▸ | MMP3 | P08254 | 2/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.48 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6726574 | 1.00 | MMP9 (0.67) | MMP9MMP2MMP1MMP13MMP14 | |
| SCHEMBL6719626 | 0.92 | MMP9 (0.58) | MMP9MMP2MMP1MMP13MMP14 | |
| SCHEMBL6719629 | 0.92 | MMP9 (0.58) | MMP9MMP2MMP1MMP13MMP14 | |
| SCHEMBL13570539 | 0.85 | MMP9 (0.80) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL13570540 | 0.85 | MMP9 (0.80) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL13570653 | 0.85 | MMP9 (0.80) | MMP9MMP2MMP1MMP13MMP3 | |
| SCHEMBL13570529 | 0.83 | MMP9 (0.80) | MMP9MMP2MMP1MMP13ADAMTS4 | |
| SCHEMBL13570580 | 0.83 | MMP9 (0.80) | MMP9MMP2MMP1MMP13ADAMTS4 | |
| SCHEMBL13570600 | 0.83 | MMP9 (0.80) | MMP9MMP2MMP1MMP13ADAMTS4 | |
| SCHEMBL25297916 | 0.81 | MMP9 (0.77) | MMP9MMP2MMP1MMP13ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |