Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL27973243 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL1577946 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL9239583 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL2179596 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL29152423 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL18684900 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL9166463 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL29152415 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL856 | 0.97 | — | — | |
| Malic Acid SCHEMBL14125844 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 134 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4521952-A1 | REACTIVE GRANULATION OF CALCIUM CITRATE MALATE, DICALCIUM MALATE, AND DIMAGNESIUM MALATE | Balchem Corporation (US) | 2025-03-19 | — | — | EP | claimed |
| WO-2023220606-A1 | REACTIVE GRANULATION OF CALCIUM CITRATE MALATE, DICALCIUM MALATE, AND DIMAGNESIUM MALATE | BALCHEM CORPORATION (US) | 2023-11-16 | — | — | WO | claimed |
| US-20230357280-A1 | REACTIVE GRANULATION OF CALCIUM CITRATE MALATE, DICALCIUM MALATE, AND DIMAGNESIUM MALATE | BALCHEM CORPORATION | 2023-11-09 | — | — | US | claimed |
| US-11534458-B2 | Phosphorus-sparing nutritional composition | ALBION LABORATORIES, INC. (US) | 2022-12-27 | — | — | US | claimed |
| CN-113678979-A | Solid beverage for promoting synthesis and secretion of insulin of type II diabetes mellitus people | 上海英库商务咨询有限公司 | 2021-11-23 | — | — | CN | claimed |
| US-20210299169-A1 | Galectin-3 Governs and Coordinates ESCRT and Autophagic Responses During Endomembrane Damage | UNM RAINFOREST INNOVATIONS | 2021-09-30 | — | — | US | claimed |
| US-20210137975-A1 | PHOSPHORUS-SPARING NUTRITIONAL COMPOSITION | JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT | 2021-05-13 | — | — | US | claimed |
| US-10912796-B2 | Phosphorus-sparing nutritional composition | ALBION LABORATORIES, INC. (US) | 2021-02-09 | — | — | US | claimed |
| EP-3733172-A1 | BUFFERED UPPER GI ABSORPTION PROMOTER | Albion Laboratories, Inc. (US) | 2020-11-04 | — | — | EP | claimed |
| EP-2758056-B1 | BUFFERED UPPER GI ABSORPTION PROMOTER | ALBION LABORATORIES INC (US) | 2020-06-24 | — | — | EP | claimed |
| US-20160015746-A1 | PHOSPHORUS-SPARING NUTRITIONAL COMPOSITION | JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT | 2016-01-21 | — | — | US | claimed |
| EP-2967117-A1 | PHOSPHORUS-SPARING NUTRITIONAL COMPOSITION | AMIP, LLC (US) | 2016-01-20 | — | — | EP | claimed |
| WO-2015113997-A1 | PROCESS FOR PRODUCING CALCIUM FORTIFIED FERMENTED DAIRY COMPOSITIONS | COMPAGNIE GERVAIS DANONE (FR) | 2015-08-06 | — | — | WO | claimed |
| WO-2015114397-A1 | PROCESS FOR PRODUCING A FORTIFIED COMPOSITION | COMPAGNIE GERVAIS DANONE (FR) | 2015-08-06 | — | — | WO | claimed |
| WO-2014159886-A1 | PHOSPHORUS-SPARING NUTRITIONAL COMPOSITION | AMIP, LLC (US) | 2014-10-02 | — | — | WO | claimed |
| US-8202546-B2 | Nutritional supplement for use under physiologically stressful conditions | VERTICAL PHARMACEUTICALS, INC. (US) | 2012-06-19 | — | — | US | claimed |
| US-20100136104-A1 | NUTRITIONAL SUPPLEMENT FOR USE UNDER PHYSIOLOGICALLY STRESSFUL CONDITIONS | CIBC BANK USA | 2010-06-03 | — | — | US | claimed |
| US-20090035385-A1 | COMPOSITIONS INCLUDING IRON | DRUGTECH CORPORATION (US) | 2009-02-05 | — | — | US | claimed |
| EP-4521952-A4 | REACTIVE GRANULATION OF CALCIUM CITRATE MALATE, DICALCIUM MALATE, AND DIMAGNESIUM MALATE | BALCHEM CORP (US) | 2025-10-08 | — | — | EP | disclosed |
| US-20070227399-A1 | COMPOSITIONS AND METHODS FOR THE PRESERVATION OF WOOD | NOVUS INTERNATIONAL INC. (US) | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11534458-B2 | Phosphorus-sparing nutritional composition | PHPT1, PPA1, PTH1R | SMN1; SMN2 1232/4885SLC22A6 662/4885TET2 1796/4885 |
| US-20210137975-A1 | PHOSPHORUS-SPARING NUTRITIONAL COMPOSITION | PHPT1, PPA1, PTH1R | SMN1; SMN2 1232/4885SLC22A6 662/4885TET2 1796/4885 |
| US-20160015746-A1 | PHOSPHORUS-SPARING NUTRITIONAL COMPOSITION | PHPT1, PPA1, PTH1R | SMN1; SMN2 1232/4885SLC22A6 662/4885TET2 1796/4885 |
| US-10912796-B2 | Phosphorus-sparing nutritional composition | PHPT1, PPA1, PTH1R | SMN1; SMN2 1232/4885SLC22A6 662/4885TET2 1796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.