Malic Acid

Malic Acid

SCHEMBL2179596

Cl.O=C(O)CC(O)C(=O)O.[CaH2]

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F

The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.88
TET2 Q6N021 6/20 0.50
TET3 O43151 2/20 0.50
SLC22A6 Q4U2R8 1/20 0.50
TET1 Q8NFU7 1/20 0.50
KDM4A O75164 2/20 0.48
KDM4C Q9H3R0 2/20 0.48
KDM2A Q9Y2K7 2/20 0.48
OR51E2 Q9H255 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
GABRR1 P24046 2/20 0.42
LMNA P02545 1/20 0.42
KMO O15229 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Malic Acid SCHEMBL7783136 0.97 SMN1; SMN2 (0.94) SMN1; SMN2TET2TET3SLC22A6TET1
Malic Acid SCHEMBL672695 0.97 SMN1; SMN2 (0.94) SMN1; SMN2TET2TET3SLC22A6TET1
Malic Acid SCHEMBL27973243 0.97 SMN1; SMN2 (0.94) SMN1; SMN2TET2TET3SLC22A6TET1
Malic Acid SCHEMBL1577946 0.97 SMN1; SMN2 (0.94) SMN1; SMN2TET2TET3SLC22A6TET1
Malic Acid SCHEMBL5365144 0.97 SMN1; SMN2 (0.94) SMN1; SMN2TET2TET3SLC22A6TET1
Malic Acid SCHEMBL6264226 0.94 SMN1; SMN2 (0.88) SMN1; SMN2TET2TET3SLC22A6TET1
Malic Acid SCHEMBL9478602 0.94 SMN1; SMN2 (0.88) SMN1; SMN2TET2TET3SLC22A6TET1
Malic Acid SCHEMBL9166463 0.94 SMN1; SMN2 (0.88) SMN1; SMN2TET2TET3SLC22A6TET1
Malic Acid SCHEMBL18684900 0.94 SMN1; SMN2 (0.88) SMN1; SMN2TET2TET3SLC22A6TET1
Malic Acid SCHEMBL9478094 0.94 SMN1; SMN2 (0.88) SMN1; SMN2TET2TET3SLC22A6TET1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9644131-B2 Alternative ligand formulations for cellulose products CP KELCO OY (FI) 2017-05-09 US disclosed
EP-2751216-A1 \"ALTERNATIVE LIGAND FORMULATIONS FOR CELLULOSE PRODUCTS\ CP Kelco Oy (FI) 2014-07-09 EP disclosed
WO-2013029864-A1 \"ALTERNATIVE LIGAND FORMULATIONS FOR CELLULOSE PRODUCTS\ CP KELCO OY (FI) 2013-03-07 WO disclosed
US-20130053283-A1 ALTERNATIVE LIGAND FORMULATIONS FOR CELLULOSE PRODUCTS CP KELCO OY (FI) 2013-02-28 US disclosed
EP-2521461-A1 STABILIZATION OF CITRUS FRUIT BEVERAGES COMPRISING SOY PROTEIN Burcon Nutrascience (MB) Corp. (CA) 2012-11-14 EP disclosed
WO-2011079398-A1 STABILIZATION OF CITRUS FRUIT BEVERAGES COMPRISING SOY PROTEIN BURCON NUTRASCIENCE (MB) CORP. (CA) 2011-07-07 WO disclosed