Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | IDO1 | P14902 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.48 |
| ▸ | JUN | P05412 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ATF1 | P18846 | 1/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726305 | 0.83 | KDM4E (0.52) | KDM4EIDO1NPSR1MAPTALDH1A1 | |
| SCHEMBL27485780 | 0.82 | KDM4E (0.60) | KDM4EIDO1NPSR1MAPTALDH1A1 | |
| SCHEMBL29076976 | 0.82 | KDM4E (0.57) | KDM4EIDO1NPSR1MAPTALDH1A1 | |
| SCHEMBL16969103 | 0.82 | IDO1 (0.61) | KDM4EIDO1NPSR1MAPTALDH1A1 | |
| SCHEMBL6377043 | 0.82 | KDM4E (0.59) | KDM4EIDO1NPSR1MAPTALDH1A1 | |
| SCHEMBL125663 | 0.81 | KDM4E (0.53) | KDM4EIDO1NPSR1MAPTALDH1A1 | |
| SCHEMBL29076975 | 0.81 | KDM4E (0.59) | KDM4EIDO1NPSR1MAPTALDH1A1 | |
| SCHEMBL18149813 | 0.81 | KDM4E (0.58) | KDM4EIDO1NPSR1MAPTALDH1A1 | |
| SCHEMBL2119119 | 0.81 | KDM4E (0.74) | KDM4EIDO1NPSR1MAPTALDH1A1 | |
| SCHEMBL5077233 | 0.81 | KDM4E (0.58) | KDM4EIDO1NPSR1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040220231-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | LEE LEN F (US) | 2004-11-04 | — | — | US | disclosed |
| US-6794396-B2 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | PHARMACIA CORPORATION | 2004-09-21 | — | — | US | disclosed |
| US-20040038939-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | PHARMACIA CORPORATION | 2004-02-26 | — | — | US | disclosed |
| US-6605624-B1 | Preventing and/or treating atherosclerosis and other coronary artery diseases | PHARMACIA CORPORATION | 2003-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038939-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | CETP, CES1, MTTP | KDM4E 1991/4885IDO1 3688/4885NPSR1 4171/4885 |
| US-20040220231-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | CETP, MTTP, LCAT | KDM4E 1743/4885IDO1 4075/4885NPSR1 4122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.