Sugi Predict

Sugi Predict / Compounds / SCHEMBL5077233

SCHEMBL5077233

SCHEMBL5077233

CCOC(=O)c1ccc(O)nc1C(F)(F)F

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 5/20 0.58
▸ NPSR1 Q6W5P4 1/20 0.52
▸ IDO1 P14902 1/20 0.50
▸ MAPT P10636 2/20 0.47
▸ CA12 O43570 2/20 0.46
▸ CA1 P00915 2/20 0.46
▸ CA2 P00918 2/20 0.46
▸ CA7 P43166 2/20 0.46
▸ CA9 Q16790 2/20 0.46
▸ CA14 Q9ULX7 2/20 0.46
▸ TSHR P16473 2/20 0.46
▸ JUN P05412 2/20 0.45
▸ NFKB1 P19838 2/20 0.45
▸ NFKB2 Q00653 2/20 0.45
▸ RELA Q04206 2/20 0.45
▸ ALDH1A1 P00352 4/20 0.44
▸ MEN1 O00255 1/20 0.43
▸ HSP90AA1 P07900 1/20 0.43
▸ CRHBP P24387 1/20 0.43
▸ KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6377043 0.86 KDM4E (0.59) KDM4ENPSR1IDO1MAPTCA12
SCHEMBL4192553 0.85 KDM4E (0.58) KDM4ENPSR1IDO1MAPTCA12
SCHEMBL474055 0.84 KDM4E (0.57) KDM4ENPSR1IDO1MAPTCA12
SCHEMBL15567052 0.84 KDM4E (0.64) KDM4ENPSR1IDO1MAPTCA12
SCHEMBL6380259 0.83 KDM4E (0.53) KDM4ENPSR1IDO1MAPTCA12
SCHEMBL6380407 0.82 KDM4E (0.56) KDM4ENPSR1IDO1MAPTCA12
SCHEMBL14381574 0.82 KDM4E (0.42) KDM4ENPSR1IDO1MAPTCA12
SCHEMBL6375898 0.81 KDM4E (0.54) KDM4ENPSR1IDO1MAPTCA12
SCHEMBL6731339 0.81 KDM4E (0.64) KDM4ENPSR1IDO1MAPTTSHR
SCHEMBL6379826 0.80 KDM4E (0.53) KDM4ENPSR1IDO1MAPTCA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250375432-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2025-12-11 — — US disclosed
US-12383540-B2 Compounds that modulates AMPA receptor function UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2025-08-12 — — US disclosed
EP-3759092-B1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION UNIV COLLEGE CARDIFF CONSULTANTS LTD (GB) 2023-12-20 — — EP disclosed
CN-112004811-B Compounds that modulate AMPA receptor function 加的夫大学学院咨询有限公司 2023-09-22 — — CN disclosed
US-20230000847-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION DRAIG THERAPEUTICS LTD (GB) 2023-01-05 — — US disclosed
US-20230000847-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION DRAIG THERAPEUTICS LTD (GB) 2023-01-05 — — US disclosed
CN-109071468-B Heterocyclic compound and preparation method and application thereof 四川科伦博泰生物医药股份有限公司 2022-09-02 — — CN disclosed
US-11298345-B2 Compounds that modulates AMPA receptor function UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2022-04-12 — — US disclosed
US-11298345-B2 Compounds that modulates AMPA receptor function UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2022-04-12 — — US disclosed
US-20210113539-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION DRAIG THERAPEUTICS LTD (GB) 2021-04-22 — — US disclosed
EP-1565442-A1 PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS GLAXO GROUP LIMITED (GB) 2005-08-24 — — EP disclosed
WO-2005074939-A1 COMBINATION OF CB2 MODULATORS AND PDE4 INHIBITORS FOR USE IN MEDICINE GLAXO GROUP LIMITED (GB) 2005-08-18 — — WO disclosed
EP-1562907-A1 PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS GLAXO GROUP LIMITED (GB) 2005-08-17 — — EP disclosed
EP-1114030-B1 PYRIDINE KETONES USEFUL AS HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2005-06-01 — — EP disclosed
WO-2004029026-A1 PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS GLAXO GROUP LIMITED (GB) 2004-04-08 — — WO disclosed
WO-2004029027-A1 PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS GLAXO GROUP LIMITED (GB) 2004-04-08 — — WO disclosed
US-6498125-B2 Pyridine ketones useful as herbicides SYNGENTA PARTICIPATIONS AG (CH) 2002-12-24 — — US disclosed
US-20020016345-A1 Pyridine ketones useful as herbicides SYNGENTA PARTICIPATIONS AG (CH) 2002-02-07 — — US disclosed
EP-1114030-A1 PYRIDINE KETONES USEFUL AS HERBICIDES Syngenta Participations AG (CH) 2001-07-11 — — EP disclosed
WO-2000015615-A1 PYRIDINE KETONES USEFUL AS HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2000-03-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230000847-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION GRIN1, GRM1, GRIN2A KDM4E 3845/4885NPSR1 78/4885IDO1 1714/4885
US-20250375432-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION GRIN1, GRM1, GRIN2A KDM4E 3318/4885NPSR1 79/4885IDO1 2161/4885
US-20210113539-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION GRIN1, GRM1, GRIN2A KDM4E 3845/4885NPSR1 78/4885IDO1 1714/4885
US-12383540-B2 Compounds that modulates AMPA receptor function GRIN1, GRM1, GRIN2A KDM4E 3845/4885NPSR1 78/4885IDO1 1714/4885
US-20020016345-A1 Pyridine ketones useful as herbicides DDT, PDHA1, IDH2 KDM4E 461/4885NPSR1 2031/4885IDO1 660/4885
US-11298345-B2 Compounds that modulates AMPA receptor function GRIN1, GRM1, GRIN2A KDM4E 3845/4885NPSR1 78/4885IDO1 1714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.