Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.56 |
| ▸ | CDK2 | P24941 | 4/20 | 0.56 |
| ▸ | GSK3B | P49841 | 4/20 | 0.56 |
| ▸ | CDC7 | O00311 | 4/20 | 0.56 |
| ▸ | PIM1 | P11309 | 3/20 | 0.56 |
| ▸ | PRKACA | P17612 | 3/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.56 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL935182 | 0.80 | CYP19A1 (1.00) | CYP19A1NPC1RAB9AROCK2CDK2 | |
| SCHEMBL15836586 | 0.80 | CYP19A1 (0.93) | CYP19A1NPC1RAB9AROCK2CDK2 | |
| SCHEMBL12022166 | 0.79 | CYP19A1 (0.84) | CYP19A1NPC1RAB9AROCK2CDK2 | |
| SCHEMBL28814340 | 0.79 | ESRRG (0.70) | CYP19A1NPC1RAB9AHSP90AA1HSP90AB1 | |
| SCHEMBL12037700 | 0.79 | CYP19A1 (0.68) | CYP19A1NPC1RAB9AHSP90AA1HSP90AB1 | |
| Acetic Acid SCHEMBL28328686 | 0.78 | CYP19A1 (0.82) | CYP19A1NPC1RAB9AGSK3BFLT3 | |
| SCHEMBL22510634 | 0.78 | CYP19A1 (0.82) | CYP19A1NPC1RAB9AROCK2CDK2 | |
| SCHEMBL12535881 | 0.77 | NPC1 (0.88) | CYP19A1NPC1RAB9AGSK3BFLT3 | |
| SCHEMBL16050564 | 0.76 | CYP19A1 (0.72) | CYP19A1NPC1RAB9AROCK2CDK2 | |
| SCHEMBL29352717 | 0.76 | CYP19A1 (0.72) | CYP19A1NPC1RAB9AROCK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |