Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.51 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | ESRRA | P11474 | 3/20 | 0.46 |
| ▸ | ESR1 | P03372 | 3/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1884295 | 0.95 | GRIA1 (0.55) | GRIA1GRIA3PDE4DGRM1ESRRA | |
| SCHEMBL1884441 | 0.92 | GRIA1 (0.58) | GRIA1GRIA3PDE4DESRRAESR1 | |
| SCHEMBL7021080 | 0.87 | GRIA1 (0.46) | GRIA1GRIA3PDE4DESR1ESR2 | |
| SCHEMBL1882707 | 0.86 | GRIA1 (0.54) | GRIA1GRIA3PDE4DGRM1GABRG2 | |
| SCHEMBL1882156 | 0.83 | GRIA1 (0.69) | GRIA1GRIA3PDE4DMAPTKDM4E | |
| SCHEMBL1882345 | 0.82 | GRIA1 (0.50) | GRIA1GRIA3PDE4DGRM1MAPK14 | |
| SCHEMBL1882491 | 0.82 | GRIA1 (0.56) | GRIA1GRIA3PDE4DESR1ESR2 | |
| SCHEMBL1881357 | 0.81 | GRIA1 (0.58) | GRIA1GRIA3PDE4DMAPTKDM4E | |
| SCHEMBL1882344 | 0.81 | GRIA1 (0.49) | GRIA1GRIA3PDE4DGRM1GABRG2 | |
| SCHEMBL1888790 | 0.80 | GRIA1 (0.79) | GRIA1GRIA3PDE4DESRRAESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465626-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | Eisai Co., Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003047577-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | EISAI CO LTD (JP) | 2003-06-12 | — | — | WO | disclosed |