Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 10/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 5/20 | 0.39 |
| ▸ | ESRRB | O95718 | 4/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1882345 | 0.96 | GRIA1 (0.50) | GRIA1GRIA3PDE4DMCHR1ACVR1B | |
| SCHEMBL1884211 | 0.92 | GRIA1 (0.48) | GRIA1GRIA3PDE4DMCHR1ACVR1B | |
| SCHEMBL1881496 | 0.88 | GRIA1 (0.49) | GRIA1GRIA3PDE4DMCHR1ACVR1B | |
| SCHEMBL6732337 | 0.87 | GRIA1 (0.51) | GRIA1GRIA3PDE4DESR1KDR | |
| SCHEMBL1884441 | 0.87 | GRIA1 (0.58) | GRIA1GRIA3PDE4DESR1ESR2 | |
| SCHEMBL1884751 | 0.82 | GRIA1 (0.53) | GRIA1GRIA3PDE4DMCHR1ACVR1B | |
| SCHEMBL1884295 | 0.82 | GRIA1 (0.55) | GRIA1GRIA3PDE4DTGFBR1KDR | |
| SCHEMBL1882344 | 0.80 | GRIA1 (0.49) | GRIA1GRIA3PDE4DMCHR1RIPK2 | |
| SCHEMBL1891974 | 0.80 | GRIA1 (0.47) | GRIA1GRIA3PDE4DRIPK2ACVR1 | |
| SCHEMBL2961989 | 0.79 | GRIA1 (0.68) | GRIA1GRIA3PDE4DMCHR1ACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300396-A1 | 1,2-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF | Eisai Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |