Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.62 |
| ▸ | NAMPT | P43490 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235869 | 0.88 | CYP1A2 (0.69) | LTA4HMAPK1ALDH1A1MAPTHTT | |
| Hydrochloric Acid SCHEMBL30115033 | 0.87 | CYP1A2 (0.67) | LTA4HMAPK1ALDH1A1MAPTHTT | |
| SCHEMBL5947356 | 0.86 | MAPK1 (0.60) | LTA4HEPHX2NAMPTMAPK1ALDH1A1 | |
| SCHEMBL8499156 | 0.85 | LTA4H (0.82) | LTA4HEPHX2OPRM1OPRD1OPRK1 | |
| SCHEMBL9081140 | 0.85 | LTA4H (0.82) | LTA4HEPHX2OPRM1OPRD1OPRK1 | |
| SCHEMBL9154589 | 0.83 | LTA4H (0.79) | LTA4HEPHX2OPRM1OPRD1OPRK1 | |
| SCHEMBL580095 | 0.82 | NAMPT (0.60) | NAMPTMAPK1OPRM1OPRD1OPRK1 | |
| SCHEMBL16606308 | 0.82 | CYP1A2 (0.74) | LTA4HALDH1A1MAPTHTTCYP1A2 | |
| SCHEMBL5947260 | 0.80 | BCHE (0.68) | LTA4HEPHX2OPRM1OPRD1OPRK1 | |
| SCHEMBL10561741 | 0.80 | CYP1A2 (0.61) | ALDH1A1MAPTHTTCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800651-B2 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2004-10-05 | — | — | US | disclosed |
| US-20040006114-A1 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2004-01-08 | — | — | US | disclosed |
| EP-1255735-A2 | PYRIDINE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001056990-A2 | PYRIDINE DERIVATES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2001-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006114-A1 | Potentiators of glutamate receptors | GRM1, GRIN1, GRM2 | LTA4H 1721/4885EPHX2 2200/4885NAMPT 3202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.