Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15472134 | 0.82 | KMT2A (0.44) | TSHRCHEK1METGSK3BLIMK1 | |
| SCHEMBL16212689 | 0.82 | TSHR (0.42) | TSHRCHEK1METGSK3BLIMK1 | |
| SCHEMBL18490206 | 0.81 | CHEK1 (0.41) | TSHRCHEK1METGSK3BLIMK1 | |
| SCHEMBL29137861 | 0.79 | TSHR (0.53) | TSHRNPC1RAB9AGAAPOLB | |
| SCHEMBL20263513 | 0.78 | TSHR (0.39) | TSHRCHEK1METGSK3BLIMK1 | |
| SCHEMBL1527614 | 0.75 | CHEK1 (0.37) | TSHRCHEK1METGSK3BLIMK1 | |
| SCHEMBL24716081 | 0.74 | KMT2A (0.47) | TSHRNPC1RAB9AGAAPOLB | |
| SCHEMBL20607510 | 0.74 | CHEK1 (0.47) | TSHRCHEK1METGSK3BLIMK1 | |
| SCHEMBL4584288 | 0.74 | TSHR (1.00) | TSHRCHEK1METGSK3BLIMK1 | |
| SCHEMBL1450859 | 0.72 | KMT2A (0.51) | TSHRNPC1RAB9APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012022776-A1 | SUBSTITUTED THIOPENES OR FURANS AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2012-02-23 | — | — | WO | disclosed |